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Overview

Uniprot IDQ06210
Protein NameGlutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Gene NameGFPT1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
48 GFDGGNDKDWEANAC
556 ATELYHQKSVLIMGR
640 RPVVICDKEDTETIK

Function

Rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP) that catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine, thereby controlling the flux of glucose into this pathway (PubMed:32019926, PubMed:35229715). Inhibited by UDP-N-acetylglucosamine (UDP-GlcNAc) through a feedback loop (PubMed:32019926, PubMed:35229715). Fine-tunes the metabolic fluctuations of UDP-GlcNAc and its impacts on hyaluronan synthesis during tissue remodeling (PubMed:26887390). Via control of the HPB, regulates the availability of precursors for N- and O-linked protein glycosylation and modulates peripheral clock oscillation (By similarity)

Protein Sequence

10 MCGIFAYLNY 20 HVPRTRREIL 30 ETLIKGLQRL 40 EYRGYDSAGV 50 GFDGGNDKDW 60 EANACKIQLI 70 KKKGKVKALD 80 EEVHKQQDMD 90 LDIEFDVHLG 100 IAHTRWATHG 110 EPSPVNSHPQ 120 RSDKNNEFIV 130 IHNGIITNYK 140 DLKKFLESKG 150 YDFESETDTE 160 TIAKLVKYMY 170 DNRESQDTSF 180 TTLVERVIQQ 190 LEGAFALVFK 200 SVHFPGQAVG 210 TRRGSPLLIG 220 VRSEHKLSTD 230 HIPILYRTAR 240 TQIGSKFTRW 250 GSQGERGKDK 260 KGSCNLSRVD 270 STTCLFPVEE 280 KAVEYYFASD 290 ASAVIEHTNR 300 VIFLEDDDVA 310 AVVDGRLSIH 320 RIKRTAGDHP 330 GRAVQTLQME 340 LQQIMKGNFS 350 SFMQKEIFEQ 360 PESVVNTMRG 370 RVNFDDYTVN 380 LGGLKDHIKE 390 IQRCRRLILI 400 ACGTSYHAGV 410 ATRQVLEELT 420 ELPVMVELAS 430 DFLDRNTPVF 440 RDDVCFFLSQ 450 SGETADTLMG 460 LRYCKERGAL 470 TVGITNTVGS 480 SISRETDCGV 490 HINAGPEIGV 500 ASTKAYTSQF 510 VSLVMFALMM 520 CDDRISMQER 530 RKEIMLGLKR 540 LPDLIKEVLS 550 MDDEIQKLAT 560 ELYHQKSVLI 570 MGRGYHYATC 580 LEGALKIKEI 590 TYMHSEGILA 600 GELKHGPLAL 610 VDKLMPVIMI 620 IMRDHTYAKC 630 QNALQQVVAR 640 QGRPVVICDK 650 EDTETIKNTK 660 RTIKVPHSVD 670 CLQGILSVIP 680 LQLLAFHLAV 690 LRGYDVDFPR NLAKSVTVE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Molecular Function GO:0097367 carbohydrate derivative binding
Molecular Function GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Biological Process GO:0032922 circadian regulation of gene expression
Biological Process GO:0006112 energy reserve metabolic process
Biological Process GO:0006002 fructose 6-phosphate metabolic process
Biological Process GO:0006487 protein N-linked glycosylation
Biological Process GO:0006048 UDP-N-acetylglucosamine biosynthetic process
Biological Process GO:0006047 UDP-N-acetylglucosamine metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.