Search Results

Overview

Uniprot IDQ06278
Protein NameAldehyde oxidase
Gene NameAOX1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1003 FNAENYWKKKGLAMV
1108 DACQTLLKRLEPIIS
1116 RLEPIISKNPKGTWK
1119 PIISKNPKGTWKDWA
1321 ACEDKFTKMIPRDEP
166 DACKTFCKTSGCCQS
258 ELLEFKFKYPQAPVI
278 VGPEVKFKGVFHPVI
330 VQKLPEEKTQMYHAL
421 VNIPYSRKWEFVSAF
474 GPATICAKNSCQKLI
479 CAKNSCQKLIGRHWN
559 ALEDLHSKHHCSTLK
566 KHHCSTLKYQNIGPK
722 SSFKPERKLEYGNVD
790 DIVASTLKLPANKVM
795 TLKLPANKVMCHVRR
810 VGGAFGGKVLKTGII
854 GRHPYLGKYKAGFMN
856 HPYLGKYKAGFMNDG
949 KCGLSPEKVRIINMY
957 VRIINMYKEIDQTPY
965 EIDQTPYKQEINAKN
995 LRKVAVEKFNAENYW

Function

Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis

Protein Sequence

10 MDRASELLFY 20 VNGRKVIEKN 30 VDPETMLLPY 40 LRKKLRLTGT 50 KYGCGGGGCG 60 ACTVMISRYN 70 PITKRIRHHP 80 ANACLIPICS 90 LYGAAVTTVE 100 GIGSTHTRIH 110 PVQERIAKCH 120 GTQCGFCTPG 130 MVMSIYTLLR 140 NHPEPTLDQL 150 TDALGGNLCR 160 CTGYRPIIDA 170 CKTFCKTSGC 180 CQSKENGVCC 190 LDQGINGLPE 200 FEEGSKTSPK 210 LFAEEEFLPL 220 DPTQELIFPP 230 ELMIMAEKQS 240 QRTRVFGSER 250 MMWFSPVTLK 260 ELLEFKFKYP 270 QAPVIMGNTS 280 VGPEVKFKGV 290 FHPVIISPDR 300 IEELSVVNHA 310 YNGLTLGAGL 320 SLAQVKDILA 330 DVVQKLPEEK 340 TQMYHALLKH 350 LGTLAGSQIR 360 NMASLGGHII 370 SRHPDSDLNP 380 ILAVGNCTLN 390 LLSKEGKRQI 400 PLNEQFLSKC 410 PNADLKPQEI 420 LVSVNIPYSR 430 KWEFVSAFRQ 440 AQRQENALAI 450 VNSGMRVFFG 460 EGDGIIRELC 470 ISYGGVGPAT 480 ICAKNSCQKL 490 IGRHWNEQML 500 DIACRLILNE 510 VSLLGSAPGG 520 KVEFKRTLII 530 SFLFKFYLEV 540 SQILKKMDPV 550 HYPSLADKYE 560 SALEDLHSKH 570 HCSTLKYQNI 580 GPKQHPEDPI 590 GHPIMHLSGV 600 KHATGEAIYC 610 DDMPLVDQEL 620 FLTFVTSSRA 630 HAKIVSIDLS 640 EALSMPGVVD 650 IMTAEHLSDV 660 NSFCFFTEAE 670 KFLATDKVFC 680 VGQLVCAVLA 690 DSEVQAKRAA 700 KRVKIVYQDL 710 EPLILTIEES 720 IQHNSSFKPE 730 RKLEYGNVDE 740 AFKVVDQILE 750 GEIHMGGQEH 760 FYMETQSMLV 770 VPKGEDQEMD 780 VYVSTQFPKY 790 IQDIVASTLK 800 LPANKVMCHV 810 RRVGGAFGGK 820 VLKTGIIAAV 830 TAFAANKHGR 840 AVRCVLERGE 850 DMLITGGRHP 860 YLGKYKAGFM 870 NDGRILALDM 880 EHYSNAGASL 890 DESLFVIEMG 900 LLKMDNAYKF 910 PNLRCRGWAC 920 RTNLPSNTAF 930 RGFGFPQAAL 940 ITESCITEVA 950 AKCGLSPEKV 960 RIINMYKEID 970 QTPYKQEINA 980 KNLIQCWREC 990 MAMSSYSLRK 1000 VAVEKFNAEN 1010 YWKKKGLAMV 1020 PLKFPVGLGS 1030 RAAGQAAALV 1040 HIYLDGSVLV 1050 THGGIEMGQG 1060 VHTKMIQVVS 1070 RELRMPMSNV 1080 HLRGTSTETV 1090 PNANISGGSV 1100 VADLNGLAVK 1110 DACQTLLKRL 1120 EPIISKNPKG 1130 TWKDWAQTAF 1140 DESINLSAVG 1150 YFRGYESDMN 1160 WEKGEGQPFE 1170 YFVYGAACSE 1180 VEIDCLTGDH 1190 KNIRTDIVMD 1200 VGCSINPAID 1210 IGQIEGAFIQ 1220 GMGLYTIEEL 1230 NYSPQGILHT 1240 RGPDQYKIPA 1250 ICDMPTELHI 1260 ALLPPSQNSN 1270 TLYSSKGLGE 1280 SGVFLGCSVF 1290 FAIHDAVSAA 1300 RQERGLHGPL 1310 TLNSPLTPEK 1320 IRMACEDKFT 1330 KMIPRDEPGS YVPWNVPI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Molecular Function GO:0051537 2 iron, 2 sulfur cluster binding
Molecular Function GO:0004031 aldehyde oxidase activity
Molecular Function GO:0071949 FAD binding
Molecular Function GO:0050660 flavin adenine dinucleotide binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0005506 iron ion binding
Molecular Function GO:0043546 molybdopterin cofactor binding
Molecular Function GO:0051287 NAD binding
Molecular Function GO:0042803 protein homodimerization activity
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0006805 xenobiotic metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.