Search Results
Overview
| Uniprot ID | Q06323 |
|---|---|
| Protein Name | Proteasome activator complex subunit 1 |
| Gene Name | PSME1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 13 | VQPEAQAKVDVFRED |
| 176 | GFHTQISKYFSERGD |
| 190 | DAVTKAAKQPHVGDY |
| 35 | LLGSYFPKKISELDA |
| 36 | LGSYFPKKISELDAF |
Function
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome
Protein Sequence
10
MAMLRVQPEA
20
QAKVDVFRED
30
LCTKTENLLG
40
SYFPKKISEL
50
DAFLKEPALN
60
EANLSNLKAP
70
LDIPVPDPVK
80
EKEKEERKKQ
90
QEKEDKDEKK
100
KGEDEDKGPP
110
CGPVNCNEKI
120
VVLLQRLKPE
130
IKDVIEQLNL
140
VTTWLQLQIP
150
RIEDGNNFGV
160
AVQEKVFELM
170
TSLHTKLEGF
180
HTQISKYFSE
190
RGDAVTKAAK
200
QPHVGDYRQL
210
VHELDEAEYR
220
DIRLMVMEIR
230
NAYAVLYDII
240
LKNFEKLKKP
RGETKGMIY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0008537 | proteasome activator complex |
| Cellular Component | GO:0000502 | proteasome complex |
| Cellular Component | GO:0034515 | proteasome storage granule |
| Molecular Function | GO:0061133 | endopeptidase activator activity |
| Biological Process | GO:0071357 | cellular response to type I interferon |
| Biological Process | GO:2000045 | regulation of G1/S transition of mitotic cell cycle |
| Biological Process | GO:0061136 | regulation of proteasomal protein catabolic process |
| Biological Process | GO:0006979 | response to oxidative stress |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.