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Overview

Uniprot IDQ06330
Protein NameRecombining binding protein suppressor of hairless
Gene NameRBPJ
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
175 SKKKQSLKNADLCIA

Function

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations (PubMed:41086914). Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity)

Protein Sequence

10 MDHTEGSPAE 20 EPPAHAPSPG 30 KFGERPPPKR 40 LTREAMRNYL 50 KERGDQTVLI 60 LHAKVAQKSY 70 GNEKRFFCPP 80 PCVYLMGSGW 90 KKKKEQMERD 100 GCSEQESQPC 110 AFIGIGNSDQ 120 EMQQLNLEGK 130 NYCTAKTLYI 140 SDSDKRKHFM 150 LSVKMFYGNS 160 DDIGVFLSKR 170 IKVISKPSKK 180 KQSLKNADLC 190 IASGTKVALF 200 NRLRSQTVST 210 RYLHVEGGNF 220 HASSQQWGAF 230 FIHLLDDDES 240 EGEEFTVRDG 250 YIHYGQTVKL 260 VCSVTGMALP 270 RLIIRKVDKQ 280 TALLDADDPV 290 SQLHKCAFYL 300 KDTERMYLCL 310 SQERIIQFQA 320 TPCPKEPNKE 330 MINDGASWTI 340 ISTDKAEYTF 350 YEGMGPVLAP 360 VTPVPVVESL 370 QLNGGGDVAM 380 LELTGQNFTP 390 NLRVWFGDVE 400 AETMYRCGES 410 MLCVVPDISA 420 FREGWRWVRQ 430 PVQVPVTLVR 440 NDGIIYSTSL 450 TFTYTPEPGP 460 RPHCSAAGAI 470 LRANSSQVPP 480 NESNTNSEGS 490 YTNASTNSTS 500 VTSSTATVVS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Biological Process GO:0060844 arterial endothelial cell fate commitment
Biological Process GO:0036302 atrioventricular canal development
Biological Process GO:0097101 blood vessel endothelial cell fate specification
Biological Process GO:0072554 blood vessel lumenization
Biological Process GO:0001974 blood vessel remodeling
Biological Process GO:0003214 cardiac left ventricle morphogenesis
Biological Process GO:0060379 cardiac muscle cell myoblast differentiation
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0035912 dorsal aorta morphogenesis
Biological Process GO:0003160 endocardium morphogenesis
Biological Process GO:0001837 epithelial to mesenchymal transition
Biological Process GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
Biological Process GO:0007507 heart development
Biological Process GO:0060716 labyrinthine layer blood vessel development
Biological Process GO:0120163 negative regulation of cold-induced thermogenesis
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0030279 negative regulation of ossification
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0007219 Notch signaling pathway
Biological Process GO:0003151 outflow tract morphogenesis
Biological Process GO:0030513 positive regulation of BMP signaling pathway
Biological Process GO:0060045 positive regulation of cardiac muscle cell proliferation
Biological Process GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:1901189 positive regulation of ephrin receptor signaling pathway
Biological Process GO:1901186 positive regulation of ERBB signaling pathway
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0007221 positive regulation of transcription of Notch receptor target
Biological Process GO:0003177 pulmonary valve development
Biological Process GO:0061344 regulation of cell adhesion involved in heart morphogenesis
Biological Process GO:0043467 regulation of generation of precursor metabolites and energy
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0060412 ventricular septum morphogenesis
Biological Process GO:0003222 ventricular trabecula myocardium morphogenesis
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0002193 MAML1-RBP-Jkappa- ICN1 complex
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0017053 transcription repressor complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:0140297 DNA-binding transcription factor binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0043565 sequence-specific DNA binding
Biological Process GO:0001525 angiogenesis
Biological Process GO:0003176 aortic valve development

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.