Search Results

Overview

Uniprot IDQ06520
Protein NameSulfotransferase 2A1
Gene NameSULT2A1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
107 LPIQLFPKSFFSSKA
113 PKSFFSSKAKVIYLM
115 SFFSSKAKVIYLMRN
197 DTGRTIEKICQFLGK
224 NSSFQSMKENKMSNY
227 FQSMKENKMSNYSLL
248 DKAQLLRKGVSGDWK
255 KGVSGDWKNHFTVAQ
268 AQAEDFDKLFQEKMA
273 FDKLFQEKMADLPRE
64 MHSKGDAKWIQSVPI

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (PubMed:14573603, PubMed:18042734, PubMed:19589875, PubMed:20102295, PubMed:21187059, PubMed:2268288, PubMed:29671343, PubMed:7678732, PubMed:7854148). Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups (PubMed:14573603, PubMed:18042734, PubMed:19589875, PubMed:20102295, PubMed:21187059, PubMed:2268288, PubMed:29671343, PubMed:7678732, PubMed:7854148). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis (PubMed:14573603, PubMed:19589875, PubMed:21187059). Plays a key role in bile acid metabolism, mediating formation of 3-sulfated bile acids (PubMed:2268288, PubMed:20102295). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (By similarity)

Protein Sequence

10 MSDDFLWFEG 20 IAFPTMGFRS 30 ETLRKVRDEF 40 VIRDEDVIIL 50 TYPKSGTNWL 60 AEILCLMHSK 70 GDAKWIQSVP 80 IWERSPWVES 90 EIGYTALSET 100 ESPRLFSSHL 110 PIQLFPKSFF 120 SSKAKVIYLM 130 RNPRDVLVSG 140 YFFWKNMKFI 150 KKPKSWEEYF 160 EWFCQGTVLY 170 GSWFDHIHGW 180 MPMREEKNFL 190 LLSYEELKQD 200 TGRTIEKICQ 210 FLGKTLEPEE 220 LNLILKNSSF 230 QSMKENKMSN 240 YSLLSVDYVV 250 DKAQLLRKGV 260 SGDWKNHFTV 270 AQAEDFDKLF 280 QEKMADLPRE LFPWE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Molecular Function GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding
Molecular Function GO:0004027 alcohol sulfotransferase activity
Molecular Function GO:0047704 bile-salt sulfotransferase activity
Molecular Function GO:0050294 steroid sulfotransferase activity
Molecular Function GO:0008146 sulfotransferase activity
Biological Process GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process
Biological Process GO:0030573 bile acid catabolic process
Biological Process GO:0008206 bile acid metabolic process
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0006068 ethanol catabolic process
Biological Process GO:0016042 lipid catabolic process
Biological Process GO:0160025 sensory perception of itch
Biological Process GO:0008202 steroid metabolic process
Biological Process GO:0051923 sulfation
Biological Process GO:0042403 thyroid hormone metabolic process
Biological Process GO:0006805 xenobiotic metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.