Search Results
Overview
| Uniprot ID | Q06546 |
|---|---|
| Protein Name | GA-binding protein alpha chain |
| Gene Name | GABPA |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 292 | KVINSSAKAAKVQRA |
| 295 | NSSAKAAKVQRAPRI |
Function
Transcription factor capable of interacting with purine rich repeats (GA repeats). Positively regulates transcription of transcriptional repressor RHIT/ZNF205 (PubMed:22306510)
Protein Sequence
10
MTKREAEELI
20
EIEIDGTEKA
30
ECTEESIVEQ
40
TYAPAECVSQ
50
AIDINEPIGN
60
LKKLLEPRLQ
70
CSLDAHEICL
80
QDIQLDPERS
90
LFDQGVKTDG
100
TVQLSVQVIS
110
YQGIEPKLNI
120
LEIVKPADTV
130
EVVIDPDAHH
140
AESEAHLVEE
150
AQVITLDGTK
160
HITTISDETS
170
EQVTRWAAAL
180
EGYRKEQERL
190
GIPYDPIQWS
200
TDQVLHWVVW
210
VMKEFSMTDI
220
DLTTLNISGR
230
ELCSLNQEDF
240
FQRVPRGEIL
250
WSHLELLRKY
260
VLASQEQQMN
270
EIVTIDQPVQ
280
IIPASVQSAT
290
PTTIKVINSS
300
AKAAKVQRAP
310
RISGEDRSSP
320
GNRTGNNGQI
330
QLWQFLLELL
340
TDKDARDCIS
350
WVGDEGEFKL
360
NQPELVAQKW
370
GQRKNKPTMN
380
YEKLSRALRY
390
YYDGDMICKV
400
QGKRFVYKFV
410
CDLKTLIGYS
420
AAELNRLVTE
430
CEQKKLAKMQ
440
LHGIAQPVTA
450
VALATASLQT
EKDN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Biological Process | GO:0007528 | neuromuscular junction development |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0038127 | ERBB signaling pathway |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.