Search Results

Overview

Uniprot ID	Q06647
Protein Name	ATP synthase peripheral stalk subunit OSCP, mitochondrial
Gene Name	Atp5po
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
192	MIVRIGEKYVDMSAK
51	ALYSAASKQKRLDQV
60	KRLDQVEKELLRVGQ
70	LRVGQLLKDPKVSLA

Function

Subunit OSCP, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity)

Protein Sequence

10 MAAPATSVLS 20 RQVRSFSTSV 30 VRPFSKLVRP 40 PVQVYGIEGR 50 YATALYSAAS 60 KQKRLDQVEK 70 ELLRVGQLLK 80 DPKVSLAVLN 90 PYIKRSIKVK 100 SLKDITTKEK 110 FSPLTANLMN 120 LLAENGRLGN 130 TQGVISAFST 140 IMSVHRGEVP 150 CTVTTAFPLD 160 EAVLSELKTV 170 LNSFLSKGQI 180 LNLEVKTDPS 190 IMGGMIVRIG 200 EKYVDMSAKS 210 KIQKLSKAMR DLL

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:1903924	estradiol binding
Molecular Function	GO:0044877	protein-containing complex binding
Molecular Function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
Biological Process	GO:0071320	cellular response to cAMP
Biological Process	GO:0071345	cellular response to cytokine stimulus
Biological Process	GO:0042776	proton motive force-driven mitochondrial ATP synthesis
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0045259	proton-transporting ATP synthase complex

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.