Search Results
Overview
| Uniprot ID | Q06945 |
|---|---|
| Protein Name | Transcription factor SOX-4 |
| Gene Name | SOX4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 217 | GVSKPHAKLILAGGG |
Function
Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:30661772). Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (By similarity). Involved in skeletal myoblast differentiation by promoting gene expression of CALD1 (PubMed:26291311)
Protein Sequence
10
MVQQTNNAEN
20
TEALLAGESS
30
DSGAGLELGI
40
ASSPTPGSTA
50
STGGKADDPS
60
WCKTPSGHIK
70
RPMNAFMVWS
80
QIERRKIMEQ
90
SPDMHNAEIS
100
KRLGKRWKLL
110
KDSDKIPFIR
120
EAERLRLKHM
130
ADYPDYKYRP
140
RKKVKSGNAN
150
SSSSAAASSK
160
PGEKGDKVGG
170
SGGGGHGGGG
180
GGGSSNAGGG
190
GGGASGGGAN
200
SKPAQKKSCG
210
SKVAGGAGGG
220
VSKPHAKLIL
230
AGGGGGGKAA
240
AAAAASFAAE
250
QAGAAALLPL
260
GAAADHHSLY
270
KARTPSASAS
280
ASSAASASAA
290
LAAPGKHLAE
300
KKVKRVYLFG
310
GLGTSSSPVG
320
GVGAGADPSD
330
PLGLYEEEGA
340
GCSPDAPSLS
350
GRSSAASSPA
360
AGRSPADHRG
370
YASLRAASPA
380
PSSAPSHASS
390
SASSHSSSSS
400
SSGSSSSDDE
410
FEDDLLDLNP
420
SSNFESMSLG
430
SFSSSSALDR
440
DLDFNFEPGS
450
GSHFEFPDYC
460
TPEVSEMISG
470
DWLESSISNL
VFTY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0003215 | cardiac right ventricle morphogenesis |
| Biological Process | GO:0071333 | cellular response to glucose stimulus |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0021782 | glial cell development |
| Biological Process | GO:0014009 | glial cell proliferation |
| Biological Process | GO:0042593 | glucose homeostasis |
| Biological Process | GO:0007507 | heart development |
| Biological Process | GO:0060993 | kidney morphogenesis |
| Biological Process | GO:0060485 | mesenchyme development |
| Biological Process | GO:0003183 | mitral valve morphogenesis |
| Biological Process | GO:0045662 | negative regulation of myoblast differentiation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0060563 | neuroepithelial cell differentiation |
| Biological Process | GO:0030182 | neuron differentiation |
| Biological Process | GO:0003357 | noradrenergic neuron differentiation |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045588 | positive regulation of gamma-delta T cell differentiation |
| Biological Process | GO:0032024 | positive regulation of insulin secretion |
| Biological Process | GO:0045663 | positive regulation of myoblast differentiation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0002328 | pro-B cell differentiation |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0043516 | regulation of DNA damage response, signal transduction by p53 class mediator |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0021510 | spinal cord development |
| Biological Process | GO:0048485 | sympathetic nervous system development |
| Biological Process | GO:0030217 | T cell differentiation |
| Biological Process | GO:0060412 | ventricular septum morphogenesis |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0035198 | miRNA binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Biological Process | GO:0035910 | ascending aorta morphogenesis |
| Biological Process | GO:0003289 | atrial septum primum morphogenesis |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0048593 | camera-type eye morphogenesis |
Reference
PMID: N/A