Overview
| Uniprot ID | Q06A95 |
|---|
| Protein Name | Polypyrimidine tract-binding protein 3 |
|---|
| Gene Name | - |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 18 |
GNDNKKFKGDRPPCS |
| 394 |
SGQRLYGKVLRATLS |
| 474 |
TEAGCSVKAFKFFQK |
| 477 |
GCSVKAFKFFQKDRK |
Function
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform
Protein Sequence
10
MNSSTPSTAN
20
GNDNKKFKGD
30
RPPCSPSRVL
40
HLRKIPSDVT
50
EAEVISLGLP
60
FGKVTNLLML
70
KGKSQAFLEM
80
ASEEAAVTMV
90
NYYTPVTPHL
100
RSQPVFIQYS
110
NHRELKTDNL
120
PNQARAQAAL
130
QAVSAVQSGS
140
LGLPGAPTNE
150
GTILPGQSPV
160
LRIIIENLFY
170
PVTLEVLHQI
180
FSKFGTVLKI
190
ITFTKNNQFQ
200
ALLQYADPLN
210
AHYAKMALDG
220
QNIYNACCTL
230
RIDFSKLTSL
240
NVKYNNDKSR
250
DFTRLDLPTG
260
DGQPSLEPPM
270
AAAFGAPGII
280
SSPYAGAAGF
290
APAIGFPQAT
300
GLSVPAGLGP
310
GALGPLAITS
320
SAVTGRMAMP
330
GTGGIPGNSV
340
LLVTNLNPDL
350
VTPHGLFILF
360
GVYGDVHRVK
370
IMFNKKENAL
380
VQMADANQAQ
390
LAMNHLSGQR
400
LYGKVLRATL
410
SKHQAVQLPR
420
EGQEDQGLTK
430
DFSNSPLHRF
440
KKPGSKNFQN
450
IFPPSATLHL
460
SNIPPSVTVD
470
DLKNLFTEAG
480
CSVKAFKFFQ
490
KDRKMALIQL
500
GSVEEAIQAL
510
IELHNHDLGE
520
NHHLRVSFSK
STI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0043249 |
erythrocyte maturation |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.