Search Results
Overview
| Uniprot ID | Q06A96 |
|---|---|
| Protein Name | U1 small nuclear ribonucleoprotein A |
| Gene Name | - |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 101 | MRGTFADKEKKKEKK |
| 111 | KKEKKKAKTVEQTAT |
| 85 | PMRIQYAKTDSDIIS |
Function
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs
Protein Sequence
10
MDIRPNHTIY
20
INNMNDKIKK
30
EELKRSLYAL
40
FSQFGHVVDI
50
VALKTMKMRG
60
QAFVIFKELG
70
SSTNALRQLQ
80
GFPFYGKPMR
90
IQYAKTDSDI
100
ISKMRGTFAD
110
KEKKKEKKKA
120
KTVEQTATTV
130
NKKPGQGTPN
140
SANTQGNATP
150
NPQVPDYPPN
160
YILFLNNLPE
170
ETNEMMLSML
180
FNQFPGFKEV
190
RLVPGRHDIA
200
FVEFENDGQA
210
GAARDALQGF
220
KITPSHAMKI
TYAKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005685 | U1 snRNP |
| Cellular Component | GO:0005686 | U2 snRNP |
| Cellular Component | GO:0071007 | U2-type catalytic step 2 spliceosome |
| Cellular Component | GO:0071005 | U2-type precatalytic spliceosome |
| Molecular Function | GO:0030619 | U1 snRNA binding |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.