Overview
| Uniprot ID | Q06A98 |
|---|
| Protein Name | Serine/arginine-rich splicing factor 2 |
|---|
| Gene Name | SRSF2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 36 |
TLRRVFEKYGRVGDV |
Function
Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment
Protein Sequence
10
MSYGRPPPDV
20
EGMTSLKVDN
30
LTYRTSPDTL
40
RRVFEKYGRV
50
GDVYIPRDRY
60
TKESRGFAFV
70
RFHDKRDAED
80
AMDAMDGAVL
90
DGRELRVQMA
100
RYGRPPDSHH
110
SRRGPPPRRY
120
GGGGYGRRSR
130
SPRRRRRSRS
140
RSRSRSRSRS
150
RSRYSRSKSR
160
SRTRSRSRST
170
SKSRSARRSK
180
SKSSSVSRSR
190
SRSRSRSRSR
200
SPPPASKRES
210
KSRSRSKSPP
220
KSPEEEGAVS
S
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0000381 |
regulation of alternative mRNA splicing, via spliceosome |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.