Search Results
Overview
| Uniprot ID | Q06AA3 |
|---|---|
| Protein Name | Regucalcin |
| Gene Name | RGN |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 239 | GKRLQTVKLPVDKTT |
Function
Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity)
Protein Sequence
10
MSSIKIECVL
20
RENCHCGESP
30
VWGEASNSLL
40
FVDIPAKKVC
50
RWNALSKQVQ
60
RVTLDAPVSS
70
VALRQAGGYV
80
ATVGTKFCAL
90
NWEDESAVVL
100
AAVDKDKKNN
110
RFNDGKVDPA
120
GRYFAGTMAE
130
ETAPAVLERH
140
QGSLYALFAD
150
HHVEKYFDQV
160
DISNGLDWSL
170
DHKIFYYIDS
180
LSYSVDAFDY
190
DLQTGKISNR
200
RSIYKMEKEE
210
HIPDGMCIDT
220
EGKLWVACYN
230
GGRVIRLDPE
240
TGKRLQTVKL
250
PVDKTTSCCF
260
GGKDYSEMYV
270
TCARDGLDPQ
280
GLLQQPEAGG
290
IFKITGLGVK
GLPPYPYAG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Biological Process | GO:0019853 | L-ascorbic acid biosynthetic process |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0030234 | enzyme regulator activity |
| Molecular Function | GO:0004341 | gluconolactonase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.