Search Results
Overview
| Uniprot ID | Q06AA4 |
|---|---|
| Protein Name | U1 small nuclear ribonucleoprotein A |
| Gene Name | SNRPA |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 114 | KREKRKPKSQETPAS |
| 122 | SQETPASKKAVQGGA |
| 20 | YINNLNEKIKKDELK |
| 98 | SDIIAKMKGTFVERD |
Function
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs (By similarity)
Protein Sequence
10
MAVPETRPNH
20
TIYINNLNEK
30
IKKDELKKSL
40
YAIFSQFGQI
50
LDILVSRSLK
60
MRGQAFVIFK
70
EVSSATNALR
80
SMQGFPFYDK
90
PMRIQYAKTD
100
SDIIAKMKGT
110
FVERDRKREK
120
RKPKSQETPA
130
SKKAVQGGAA
140
APVVGAVQGP
150
VPGMPPMTQT
160
PRIMHHMPGQ
170
PPYMPPPGMI
180
PPPGLAPGQI
190
PPGAMPPQQL
200
MPGQMPPAQP
210
LSENPPNHIL
220
FLTNLPEETN
230
ELMLSMLFNQ
240
FPGFKEVRLV
250
PGRHDIAFVE
260
FDNEVQAGAA
270
RDALQGFKIT
280
QNNAMKISFA
KK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005681 | spliceosomal complex |
| Cellular Component | GO:0005685 | U1 snRNP |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0030619 | U1 snRNA binding |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.