Overview
| Uniprot ID | Q06AA9 |
|---|
| Protein Name | Ubiquitin-conjugating enzyme E2 D2 |
|---|
| Gene Name | UBE2D2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 8 |
MALKRIHKELNDLAR |
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and SQSTM1 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection. Essential for viral activation of IRF3
Protein Sequence
10
MALKRIHKEL
20
NDLARDPPAQ
30
CSAGPVGDDM
40
FHWQATIMGP
50
NDSPYQGGVF
60
FLTIHFPTDY
70
PFKPPKVAFT
80
TRIYHPNINS
90
NGSICLDILR
100
SQWSPALTIS
110
KVLLSICSLL
120
CDPNPDDPLV
130
PEIARIYKTD
140
RDKYNRISRE
WTQKYAM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0061631 |
ubiquitin conjugating enzyme activity |
| Molecular Function |
GO:0004842 |
ubiquitin-protein transferase activity |
| Biological Process |
GO:0070979 |
protein K11-linked ubiquitination |
| Biological Process |
GO:0070936 |
protein K48-linked ubiquitination |
| Biological Process |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.