Search Results
Overview
| Uniprot ID | Q06AT3 |
|---|---|
| Protein Name | Ubiquitin carboxyl-terminal hydrolase isozyme L5 |
| Gene Name | UCHL5 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 282 | VQKLKRYKIENIRRK |
| 315 | QLIPLVEKAKEKQNA |
Function
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity)
Protein Sequence
10
MTGNAGEWCL
20
MESDPGVFTE
30
LIKGFGCRGA
40
QVEEIWSLEP
50
ENFEKLKPVH
60
GLIFLFKWQP
70
GEEPAGSVVQ
80
DSRLDTIFFA
90
KQVINNACAT
100
QAIVSVLLNC
110
THQDVHLGET
120
LSEFKEFSQS
130
FDAAMKGLAL
140
SNSDVIRQVH
150
NSFARQQMFE
160
FDAKTSAKEE
170
DAFHFVSYVP
180
VNGRLYELDG
190
LREGPIDLGA
200
CNQDDWISAV
210
RPVIEKRIQK
220
YSEGEIRFNL
230
MAIVSDRKMI
240
YEQKIAELQR
250
QLAEEEPMDT
260
DQGSNMLSAI
270
QSEVAKNQML
280
IEEEVQKLKR
290
YKIENIRRKH
300
NYLPFIMELL
310
KTLAEHQQLI
320
PLVEKAKEKQ
NAKKAQETK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031011 | Ino80 complex |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000502 | proteasome complex |
| Molecular Function | GO:0004843 | cysteine-type deubiquitinase activity |
| Molecular Function | GO:0070628 | proteasome binding |
| Biological Process | GO:0006310 | DNA recombination |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0016579 | protein deubiquitination |
| Biological Process | GO:0033044 | regulation of chromosome organization |
| Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.