Overview
| Uniprot ID | Q06AU4 |
|---|
| Protein Name | Ras-related protein Rab-34 |
|---|
| Gene Name | RAB34 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 22 |
ELPQCLRKEAALHVR |
| 74 |
CLINRFCKDTFDKNY |
| 79 |
FCKDTFDKNYKATIG |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB34 transports protein involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (By similarity). Plays a role in the fusion of phagosomes with lysosomes (By similarity). Required for the early steps of intracellular ciliogenesis, the cilium assembly pathway initiated by trafficking and docking of ciliary vesicles to the centrioles in the cytoplasm, followed by axoneme formation in the cytoplasm. After axoneme elongation, the centrioles migrate close to the cell surface so that ciliary vesicles can fuse with the plasma membrane to expose cilia to the extracellular space. It seems dispensable for ciliogenesis via the extracellular pathway where cilium assembly begins after migration and docking of the centriole to the plasma membrane. Also acts as a positive regulator of hedgehog signaling and regulates ciliary function (By similarity)
Protein Sequence
10
MNILAPVRRD
20
RVLAELPQCL
30
RKEAALHVRK
40
DFHPRVTCAC
50
QEHRTGTVGF
60
KISKVIVVGD
70
LSVGKTCLIN
80
RFCKDTFDKN
90
YKATIGVDFE
100
MERFEVLGVP
110
FSLQLWDTAG
120
QERFKCIAST
130
YYRGAQAIII
140
VFNLNDVASL
150
EHTKQWLADA
160
LKENDPSSVL
170
LFLVGSKKDL
180
STPAQYVLME
190
KDALKVAHEM
200
KAEYWAVSSL
210
TGENVREFFF
220
RVAALTFEAN
230
VLAELEKSGS
240
RRIGDVVRLN
250
SDDSNLYLTA
SKKKPACCP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005814 |
centriole |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0005929 |
cilium |
| Cellular Component |
GO:0031985 |
Golgi cisterna |
| Cellular Component |
GO:0045335 |
phagocytic vesicle |
| Cellular Component |
GO:0030670 |
phagocytic vesicle membrane |
| Molecular Function |
GO:0003925 |
G protein activity |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0060271 |
cilium assembly |
| Biological Process |
GO:0061824 |
cytosolic ciliogenesis |
| Biological Process |
GO:0043001 |
Golgi to plasma membrane protein transport |
| Biological Process |
GO:0090382 |
phagosome maturation |
| Biological Process |
GO:0090385 |
phagosome-lysosome fusion |
| Biological Process |
GO:0045880 |
positive regulation of smoothened signaling pathway |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.