Overview
| Uniprot ID | Q06AU7 |
|---|
| Protein Name | Ras-related protein Rab-1B |
|---|
| Gene Name | RAB1B |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 122 |
NKLLVGNKSDLTTKK |
| 128 |
NKSDLTTKKVVDNTT |
| 129 |
KSDLTTKKVVDNTTA |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Required to modulate the compacted morphology of the Golgi. Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity)
Protein Sequence
10
MNPEYDYLFK
20
LLLIGDSGVG
30
KSCLLLRFAD
40
DTYTESYIST
50
IGVDFKIRTI
60
ELDGKTIKLQ
70
IWDTAGQERG
80
RTITSSYYRG
90
AHGIIVVYDV
100
TDQESYANVK
110
QWLQEIDRYA
120
SENVNKLLVG
130
NKSDLTTKKV
140
VDNTTAKEFA
150
DSLGIPFLET
160
SAKNATNVEQ
170
AFMTMAAEIK
180
KRMGPGAASG
190
GERPNLKIDS
200
TPVKQAGGGC
C
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0034045 |
phagophore assembly site membrane |
| Molecular Function |
GO:0003925 |
G protein activity |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0006914 |
autophagy |
| Biological Process |
GO:0007030 |
Golgi organization |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0016192 |
vesicle-mediated transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.