Search Results

Overview

Uniprot IDQ07065
Protein NameCytoskeleton-associated protein 4
Gene NameCKAP4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
10 SAKQRGSKGGHGAAS
182 ILRSSQHKQDLTEKA
21 GAASPSEKGAHPSGG
223 SDGIHVVKDARERDF
272 EINDMKAKVASLEES
283 LEESEGNKQDLKALK
294 KALKEAVKEIQTSAK
332 VRELVSLKQEQQAFK
339 KQEQQAFKEAADTER
355 ALQALTEKLLRSEES
381 EEELRQLKSDSHGPK
388 KSDSHGPKEDGGFRH
405 AFEALQQKSQGLDSR

Function

Mediates the anchoring of the endoplasmic reticulum to microtubules

Protein Sequence

10 MPSAKQRGSK 20 GGHGAASPSE 30 KGAHPSGGAD 40 DVAKKPPPAP 50 QQPPPPPAPH 60 PQQHPQQHPQ 70 NQAHGKGGHR 80 GGGGGGGKSS 90 SSSSASAAAA 100 AAAASSSASC 110 SRRLGRALNF 120 LFYLALVAAA 130 AFSGWCVHHV 140 LEEVQQVRRS 150 HQDFSRQREE 160 LGQGLQGVEQ 170 KVQSLQATFG 180 TFESILRSSQ 190 HKQDLTEKAV 200 KQGESEVSRI 210 SEVLQKLQNE 220 ILKDLSDGIH 230 VVKDARERDF 240 TSLENTVEER 250 LTELTKSIND 260 NIAIFTEVQK 270 RSQKEINDMK 280 AKVASLEESE 290 GNKQDLKALK 300 EAVKEIQTSA 310 KSREWDMEAL 320 RSTLQTMESD 330 IYTEVRELVS 340 LKQEQQAFKE 350 AADTERLALQ 360 ALTEKLLRSE 370 ESVSRLPEEI 380 RRLEEELRQL 390 KSDSHGPKED 400 GGFRHSEAFE 410 ALQQKSQGLD 420 SRLQHVEDGV 430 LSMQVASARQ 440 TESLESLLSK 450 SQEHEQRLAA 460 LQGRLEGLGS 470 SEADQDGLAS 480 TVRSLGETQL 490 VLYGDVEELK 500 RSVGELPSTV 510 ESLQKVQEQV 520 HTLLSQDQAQ 530 AARLPPQDFL 540 DRLSSLDNLK 550 ASVSQVEADL 560 KMLRTAVDSL 570 VAYSVKIETN 580 ENNLESAKGL 590 LDDLRNDLDR 600 LFVKVEKIHE KV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0035577 azurophil granule membrane
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0042599 lamellar body
Cellular Component GO:0005811 lipid droplet
Cellular Component GO:0016020 membrane
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0005791 rough endoplasmic reticulum
Cellular Component GO:0035579 specific granule membrane
Molecular Function GO:0003723 RNA binding

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.