Search Results
Overview
| Uniprot ID | Q07266 |
|---|---|
| Protein Name | Drebrin |
| Gene Name | Dbn1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 173 | TDAAVEMKRINREQF |
| 238 | QIEEHRRKQQSLEAE |
| 248 | SLEAEEAKRRLKDQS |
| 252 | EEAKRRLKDQSIFGD |
| 270 | EEEESQMKKSESEVE |
| 437 | LDGEEVCKEAKVAAA |
Function
Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (By similarity). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (By similarity). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity)
Protein Sequence
10
MAGVSFSGHR
20
LELLAAYEEV
30
IREESAADWA
40
LYTYEDGSDD
50
LKLAASGEGG
60
LQELSGHFEN
70
QKVMYGFCSV
80
KDSQAALPKY
90
VLINWVGEDV
100
PDARKCACAS
110
HVAKVAEFFQ
120
GVDVIVNASS
130
VEDIDAGAIG
140
QRLSNGLARL
150
SSPVLHRLRL
160
REDENAEPVG
170
TTYQKTDAAV
180
EMKRINREQF
190
WEQAKKEEEL
200
RKEEERKKAL
210
DARLRFEQER
220
MEQERQEQEE
230
RERRYREREQ
240
QIEEHRRKQQ
250
SLEAEEAKRR
260
LKDQSIFGDQ
270
RDEEEESQMK
280
KSESEVEEAA
290
AIIAQRPDNP
300
REFFRQQERV
310
ASASGGSCDA
320
PSPFNHRPGR
330
PYCPFIKASD
340
SGPSSSSSSS
350
SSPPRTPFPY
360
ITCHRTPNLS
370
SSLPCSHLDS
380
HRRMAPTPIP
390
TRSPSDSSTA
400
STPITEQIER
410
ALDEVTSSQP
420
PPPPPPPPPA
430
QEAQESAPRL
440
DGEEVCKEAK
450
VAAAPQVWAG
460
CAEEPPRAQE
470
PPLLQSSPTE
480
DLMCTESPEQ
490
AVLAASPEPD
500
ASVTSVADAH
510
AADTIETTTA
520
TTATTIADNV
530
TPAAASLIDL
540
WPGNGEEAST
550
PQAEPRVPTP
560
PSGAEASLAE
570
VPLLNEAAQE
580
PLPPVGEGCA
590
NLLNFDELPE
600
PPATFCDPEE
610
EAEGEPLAAS
620
QVLTMPSALE
630
EVDQVLEQEL
640
EPEPHLLTNG
650
ETTQKEGTQQ
660
ASEGYFSQSQ
670
EEEFAQSEEP
680
CAKAPPPVFY
690
NKPPEIDITC
700
WDADPVPEEE
EGFEGGD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0032279 | asymmetric synapse |
| Cellular Component | GO:0044295 | axonal growth cone |
| Cellular Component | GO:0044308 | axonal spine |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0030864 | cortical actin cytoskeleton |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:1902737 | dendritic filopodium |
| Cellular Component | GO:0043198 | dendritic shaft |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0060076 | excitatory synapse |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0005921 | gap junction |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0044309 | neuron spine |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098871 | postsynaptic actin cytoskeleton |
| Cellular Component | GO:0099524 | postsynaptic cytosol |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Cellular Component | GO:0030427 | site of polarized growth |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0140661 | cytoskeletal motor inhibitor activity |
| Molecular Function | GO:0008092 | cytoskeletal protein binding |
| Molecular Function | GO:0005522 | profilin binding |
| Molecular Function | GO:0140311 | protein sequestering activity |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0010643 | cell communication by chemical coupling |
| Biological Process | GO:0010644 | cell communication by electrical coupling |
| Biological Process | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| Biological Process | GO:0071356 | cellular response to tumor necrosis factor |
| Biological Process | GO:0071481 | cellular response to X-ray |
| Biological Process | GO:0048699 | generation of neurons |
| Biological Process | GO:0001701 | in utero embryonic development |
| Biological Process | GO:0048286 | lung alveolus development |
| Biological Process | GO:0032507 | maintenance of protein location in cell |
| Biological Process | GO:0098828 | modulation of inhibitory postsynaptic potential |
| Biological Process | GO:0032232 | negative regulation of actin filament bundle assembly |
| Biological Process | GO:0090327 | negative regulation of locomotion involved in locomotory behavior |
| Biological Process | GO:1904113 | negative regulation of muscle filament sliding |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0061351 | neural precursor cell proliferation |
| Biological Process | GO:0048812 | neuron projection morphogenesis |
| Biological Process | GO:0045773 | positive regulation of axon extension |
| Biological Process | GO:0010811 | positive regulation of cell-substrate adhesion |
| Biological Process | GO:0061003 | positive regulation of dendritic spine morphogenesis |
| Biological Process | GO:2000463 | positive regulation of excitatory postsynaptic potential |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:1902685 | positive regulation of receptor localization to synapse |
| Biological Process | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| Biological Process | GO:0031915 | positive regulation of synaptic plasticity |
| Biological Process | GO:0098974 | postsynaptic actin cytoskeleton organization |
| Biological Process | GO:0060134 | prepulse inhibition |
| Biological Process | GO:0030833 | regulation of actin filament polymerization |
| Biological Process | GO:0051489 | regulation of filopodium assembly |
| Biological Process | GO:1902897 | regulation of postsynaptic density protein 95 clustering |
| Biological Process | GO:0014823 | response to activity |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0007283 | spermatogenesis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.