Search Results
Overview
| Uniprot ID | Q07283 |
|---|---|
| Protein Name | Trichohyalin |
| Gene Name | TCHH |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1532 | HRQQRQRKFLQEEQQ |
Function
Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation
Protein Sequence
10
MSPLLRSICD
20
ITEIFNQYVS
30
HDCDGAALTK
40
KDLKNLLERE
50
FGAVLRRPHD
60
PKTVDLILEL
70
LDLDSNGRVD
80
FNEFLLFIFK
90
VAQACYYALG
100
QATGLDEEKR
110
ARCDGKESLL
120
QDRRQEEDQR
130
RFEPRDRQLE
140
EEPGQRRRQK
150
RQEQERELAE
160
GEEQSEKQER
170
LEQRDRQRRD
180
EELWRQRQEW
190
QEREERRAEE
200
EQLQSCKGHE
210
TEEFPDEEQL
220
RRRELLELRR
230
KGREEKQQQR
240
RERQDRVFQE
250
EEEKEWRKRE
260
TVLRKEEEKL
270
QEEEPQRQRE
280
LQEEEEQLRK
290
LERQELRRER
300
QEEEQQQQRL
310
RREQQLRRKQ
320
EEERREQQEE
330
RREQQERREQ
340
QEERREQQLR
350
REQEERREQQ
360
LRREQEEERR
370
EQQLRREQEE
380
ERREQQLRRE
390
QQLRREQQLR
400
REQQLRREQQ
410
LRREQQLRRE
420
QQLRREQQLR
430
REQQLRREQE
440
EERHEQKHEQ
450
ERREQRLKRE
460
QEERRDWLKR
470
EEETERHEQE
480
RRKQQLKRDQ
490
EEERRERWLK
500
LEEEERREQQ
510
ERREQQLRRE
520
QEERREQRLK
530
RQEEEERLQQ
540
RLRSEQQLRR
550
EQEERREQLL
560
KREEEKRLEQ
570
ERREQRLKRE
580
QEERRDQLLK
590
REEERRQQRL
600
KREQEERLEQ
610
RLKREEVERL
620
EQEERREQRL
630
KREEPEEERR
640
QQLLKSEEQE
650
ERRQQQLRRE
660
QQERREQRLK
670
REEEEERLEQ
680
RLKREHEEER
690
REQELAEEEQ
700
EQARERIKSR
710
IPKWQWQLES
720
EADARQSKVY
730
SRPRKQEGQR
740
RRQEQEEKRR
750
RRESELQWQE
760
EERAHRQQQE
770
EEQRRDFTWQ
780
WQAEEKSERG
790
RQRLSARPPL
800
REQRERQLRA
810
EERQQREQRF
820
LPEEEEKEQR
830
RRQRREREKE
840
LQFLEEEEQL
850
QRRERAQQLQ
860
EEEDGLQEDQ
870
ERRRSQEQRR
880
DQKWRWQLEE
890
ERKRRRHTLY
900
AKPALQEQLR
910
KEQQLLQEEE
920
EELQREEREK
930
RRRQEQERQY
940
REEEQLQQEE
950
EQLLREEREK
960
RRRQERERQY
970
RKDKKLQQKE
980
EQLLGEEPEK
990
RRRQEREKKY
1000
REEEELQQEE
1010
EQLLREEREK
1020
RRRQEWERQY
1030
RKKDELQQEE
1040
EQLLREEREK
1050
RRLQERERQY
1060
REEEELQQEE
1070
EQLLGEERET
1080
RRRQELERQY
1090
RKEEELQQEE
1100
EQLLREEPEK
1110
RRRQERERQC
1120
REEEELQQEE
1130
EQLLREEREK
1140
RRRQELERQY
1150
REEEEVQQEE
1160
EQLLREEPEK
1170
RRRQELERQY
1180
REEEELQQEE
1190
EQLLREEQEK
1200
RRQERERQYR
1210
EEEELQRQKR
1220
KQRYRDEDQR
1230
SDLKWQWEPE
1240
KENAVRDNKV
1250
YCKGRENEQF
1260
RQLEDSQLRD
1270
RQSQQDLQHL
1280
LGEQQERDRE
1290
QERRRWQQRD
1300
RHFPEEEQLE
1310
REEQKEAKRR
1320
DRKSQEEKQL
1330
LREEREEKRR
1340
RQETDRKFRE
1350
EEQLLQEREE
1360
QPLRRQERDR
1370
KFREEELRHQ
1380
EQGRKFLEEE
1390
QRLRRQERER
1400
KFLKEEQQLR
1410
CQEREQQLRQ
1420
DRDRKFREEE
1430
QQLSRQERDR
1440
KFREEEQQVR
1450
RQERERKFLE
1460
EEQQLRQERH
1470
RKFREEEQLL
1480
QEREEQQLHR
1490
QERDRKFLEE
1500
EQQLRRQERD
1510
RKFREQELRS
1520
QEPERKFLEE
1530
EQQLHRQQRQ
1540
RKFLQEEQQL
1550
RRQERGQQRR
1560
QDRDRKFREE
1570
EQLRQEREEQ
1580
QLSRQERDRK
1590
FRLEEQKVRR
1600
QEQERKFMED
1610
EQQLRRQEGQ
1620
QQLRQERDRK
1630
FREDEQLLQE
1640
REEQQLHRQE
1650
RDRKFLEEEP
1660
QLRRQEREQQ
1670
LRHDRDRKFR
1680
EEEQLLQEGE
1690
EQQLRRQERD
1700
RKFREEEQQL
1710
RRQERERKFL
1720
QEEQQLRRQE
1730
LERKFREEEQ
1740
LRQETEQEQL
1750
RRQERYRKIL
1760
EEEQLRPERE
1770
EQQLRRQERD
1780
RKFREEEQLR
1790
QEREEQQLRS
1800
QESDRKFREE
1810
EQLRQEREEQ
1820
QLRPQQRDGK
1830
YRWEEEQLQL
1840
EEQEQRLRQE
1850
RDRQYRAEEQ
1860
FATQEKSRRE
1870
EQELWQEEEQ
1880
KRRQERERKL
1890
REEHIRRQQK
1900
EEQRHRQVGE
1910
IKSQEGKGHG
1920
RLLEPGTHQF
1930
ASVPVRSSPL
1940
YEYIQEQRSQ
YRP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001533 | cornified envelope |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0046914 | transition metal ion binding |
| Biological Process | GO:0045109 | intermediate filament organization |
| Biological Process | GO:0031424 | keratinization |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.