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Overview

Uniprot IDQ07283
Protein NameTrichohyalin
Gene NameTCHH
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1532 HRQQRQRKFLQEEQQ

Function

Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation

Protein Sequence

10 MSPLLRSICD 20 ITEIFNQYVS 30 HDCDGAALTK 40 KDLKNLLERE 50 FGAVLRRPHD 60 PKTVDLILEL 70 LDLDSNGRVD 80 FNEFLLFIFK 90 VAQACYYALG 100 QATGLDEEKR 110 ARCDGKESLL 120 QDRRQEEDQR 130 RFEPRDRQLE 140 EEPGQRRRQK 150 RQEQERELAE 160 GEEQSEKQER 170 LEQRDRQRRD 180 EELWRQRQEW 190 QEREERRAEE 200 EQLQSCKGHE 210 TEEFPDEEQL 220 RRRELLELRR 230 KGREEKQQQR 240 RERQDRVFQE 250 EEEKEWRKRE 260 TVLRKEEEKL 270 QEEEPQRQRE 280 LQEEEEQLRK 290 LERQELRRER 300 QEEEQQQQRL 310 RREQQLRRKQ 320 EEERREQQEE 330 RREQQERREQ 340 QEERREQQLR 350 REQEERREQQ 360 LRREQEEERR 370 EQQLRREQEE 380 ERREQQLRRE 390 QQLRREQQLR 400 REQQLRREQQ 410 LRREQQLRRE 420 QQLRREQQLR 430 REQQLRREQE 440 EERHEQKHEQ 450 ERREQRLKRE 460 QEERRDWLKR 470 EEETERHEQE 480 RRKQQLKRDQ 490 EEERRERWLK 500 LEEEERREQQ 510 ERREQQLRRE 520 QEERREQRLK 530 RQEEEERLQQ 540 RLRSEQQLRR 550 EQEERREQLL 560 KREEEKRLEQ 570 ERREQRLKRE 580 QEERRDQLLK 590 REEERRQQRL 600 KREQEERLEQ 610 RLKREEVERL 620 EQEERREQRL 630 KREEPEEERR 640 QQLLKSEEQE 650 ERRQQQLRRE 660 QQERREQRLK 670 REEEEERLEQ 680 RLKREHEEER 690 REQELAEEEQ 700 EQARERIKSR 710 IPKWQWQLES 720 EADARQSKVY 730 SRPRKQEGQR 740 RRQEQEEKRR 750 RRESELQWQE 760 EERAHRQQQE 770 EEQRRDFTWQ 780 WQAEEKSERG 790 RQRLSARPPL 800 REQRERQLRA 810 EERQQREQRF 820 LPEEEEKEQR 830 RRQRREREKE 840 LQFLEEEEQL 850 QRRERAQQLQ 860 EEEDGLQEDQ 870 ERRRSQEQRR 880 DQKWRWQLEE 890 ERKRRRHTLY 900 AKPALQEQLR 910 KEQQLLQEEE 920 EELQREEREK 930 RRRQEQERQY 940 REEEQLQQEE 950 EQLLREEREK 960 RRRQERERQY 970 RKDKKLQQKE 980 EQLLGEEPEK 990 RRRQEREKKY 1000 REEEELQQEE 1010 EQLLREEREK 1020 RRRQEWERQY 1030 RKKDELQQEE 1040 EQLLREEREK 1050 RRLQERERQY 1060 REEEELQQEE 1070 EQLLGEERET 1080 RRRQELERQY 1090 RKEEELQQEE 1100 EQLLREEPEK 1110 RRRQERERQC 1120 REEEELQQEE 1130 EQLLREEREK 1140 RRRQELERQY 1150 REEEEVQQEE 1160 EQLLREEPEK 1170 RRRQELERQY 1180 REEEELQQEE 1190 EQLLREEQEK 1200 RRQERERQYR 1210 EEEELQRQKR 1220 KQRYRDEDQR 1230 SDLKWQWEPE 1240 KENAVRDNKV 1250 YCKGRENEQF 1260 RQLEDSQLRD 1270 RQSQQDLQHL 1280 LGEQQERDRE 1290 QERRRWQQRD 1300 RHFPEEEQLE 1310 REEQKEAKRR 1320 DRKSQEEKQL 1330 LREEREEKRR 1340 RQETDRKFRE 1350 EEQLLQEREE 1360 QPLRRQERDR 1370 KFREEELRHQ 1380 EQGRKFLEEE 1390 QRLRRQERER 1400 KFLKEEQQLR 1410 CQEREQQLRQ 1420 DRDRKFREEE 1430 QQLSRQERDR 1440 KFREEEQQVR 1450 RQERERKFLE 1460 EEQQLRQERH 1470 RKFREEEQLL 1480 QEREEQQLHR 1490 QERDRKFLEE 1500 EQQLRRQERD 1510 RKFREQELRS 1520 QEPERKFLEE 1530 EQQLHRQQRQ 1540 RKFLQEEQQL 1550 RRQERGQQRR 1560 QDRDRKFREE 1570 EQLRQEREEQ 1580 QLSRQERDRK 1590 FRLEEQKVRR 1600 QEQERKFMED 1610 EQQLRRQEGQ 1620 QQLRQERDRK 1630 FREDEQLLQE 1640 REEQQLHRQE 1650 RDRKFLEEEP 1660 QLRRQEREQQ 1670 LRHDRDRKFR 1680 EEEQLLQEGE 1690 EQQLRRQERD 1700 RKFREEEQQL 1710 RRQERERKFL 1720 QEEQQLRRQE 1730 LERKFREEEQ 1740 LRQETEQEQL 1750 RRQERYRKIL 1760 EEEQLRPERE 1770 EQQLRRQERD 1780 RKFREEEQLR 1790 QEREEQQLRS 1800 QESDRKFREE 1810 EQLRQEREEQ 1820 QLRPQQRDGK 1830 YRWEEEQLQL 1840 EEQEQRLRQE 1850 RDRQYRAEEQ 1860 FATQEKSRRE 1870 EQELWQEEEQ 1880 KRRQERERKL 1890 REEHIRRQQK 1900 EEQRHRQVGE 1910 IKSQEGKGHG 1920 RLLEPGTHQF 1930 ASVPVRSSPL 1940 YEYIQEQRSQ YRP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0001533 cornified envelope
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0046914 transition metal ion binding
Biological Process GO:0045109 intermediate filament organization
Biological Process GO:0031424 keratinization

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.