Overview
| Uniprot ID | Q07417 |
|---|
| Protein Name | Short-chain specific acyl-CoA dehydrogenase, mitochondrial |
|---|
| Gene Name | Acads |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 51 |
TCRDFAEKELVPIAA |
| 72 |
LFPTAQVKKMGELGL |
Function
Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains
Protein Sequence
10
MAAALLARAR
20
GPLRRALGVR
30
DWRRLHTVYQ
40
SVELPETHQM
50
LRQTCRDFAE
60
KELVPIAAQL
70
DREHLFPTAQ
80
VKKMGELGLL
90
AMDVPEELSG
100
AGLDYLAYSI
110
ALEEISRACA
120
STGVIMSVNN
130
SLYLGPILKF
140
GSAQQKQQWI
150
TPFTNGDKIG
160
CFALSEPGNG
170
SDAGAASTTA
180
REEGDSWVLN
190
GTKAWITNSW
200
EASATVVFAS
210
TDRSRQNKGI
220
SAFLVPMPTP
230
GLTLGKKEDK
240
LGIRASSTAN
250
LIFEDCRIPK
260
ENLLGEPGMG
270
FKIAMQTLDM
280
GRIGIASQAL
290
GIAQASLDCA
300
VKYAENRNAF
310
GAPLTKLQNI
320
QFKLADMALA
330
LESARLLTWR
340
AAMLKDNKKP
350
FTKESAMAKL
360
AASEAATAIS
370
HQAIQILGGM
380
GYVTEMPAER
390
YYRDARITEI
400
YEGTSEIQRL
410
VIAGHLLRSY
RS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0003995 |
acyl-CoA dehydrogenase activity |
| Molecular Function |
GO:0071949 |
FAD binding |
| Molecular Function |
GO:0050660 |
flavin adenine dinucleotide binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0016937 |
short-chain fatty acyl-CoA dehydrogenase activity |
| Biological Process |
GO:0046359 |
butyrate catabolic process |
| Biological Process |
GO:0033539 |
fatty acid beta-oxidation using acyl-CoA dehydrogenase |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.