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Overview

Uniprot IDQ07864
Protein NameDNA polymerase epsilon catalytic subunit A
Gene NamePOLE
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1174 LHKKLLEKNDVYKQK
1230 PAAPVTVKRKRVLWE

Function

Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199). Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374)

Protein Sequence

10 MSLRSGGRRR 20 ADPGADGEAS 30 RDDGATSSVS 40 ALKRLERSQW 50 TDKMDLRFGF 60 ERLKEPGEKT 70 GWLINMHPTE 80 ILDEDKRLGS 90 AVDYYFIQDD 100 GSRFKVALPY 110 KPYFYIATRK 120 GCEREVSSFL 130 SKKFQGKIAK 140 VETVPKEDLD 150 LPNHLVGLKR 160 NYIRLSFHTV 170 EDLVKVRKEI 180 SPAVKKNREQ 190 DHASDAYTAL 200 LSSVLQRGGV 210 ITDEEETSKK 220 IADQLDNIVD 230 MREYDVPYHI 240 RLSIDLKIHV 250 AHWYNVRYRG 260 NAFPVEITRR 270 DDLVERPDPV 280 VLAFDIETTK 290 LPLKFPDAET 300 DQIMMISYMI 310 DGQGYLITNR 320 EIVSEDIEDF 330 EFTPKPEYEG 340 PFCVFNEPDE 350 AHLIQRWFEH 360 VQETKPTIMV 370 TYNGDFFDWP 380 FVEARAAVHG 390 LSMQQEIGFQ 400 KDSQGEYKAP 410 QCIHMDCLRW 420 VKRDSYLPVG 430 SHNLKAAAKA 440 KLGYDPVELD 450 PEDMCRMATE 460 QPQTLATYSV 470 SDAVATYYLY 480 MKYVHPFIFA 490 LCTIIPMEPD 500 EVLRKGSGTL 510 CEALLMVQAF 520 HANIIFPNKQ 530 EQEFNKLTDD 540 GHVLDSETYV 550 GGHVEALESG 560 VFRSDIPCRF 570 RMNPAAFDFL 580 LQRVEKTLRH 590 ALEEEEKVPV 600 EQVTNFEEVC 610 DEIKSKLASL 620 KDVPSRIECP 630 LIYHLDVGAM 640 YPNIILTNRL 650 QPSAMVDEAT 660 CAACDFNKPG 670 ANCQRKMAWQ 680 WRGEFMPASR 690 SEYHRIQHQL 700 ESEKFPPLFP 710 EGPARAFHEL 720 SREEQAKYEK 730 RRLADYCRKA 740 YKKIHITKVE 750 ERLTTICQRE 760 NSFYVDTVRA 770 FRDRRYEFKG 780 LHKVWKKKLS 790 AAVEVGDAAE 800 VKRCKNMEVL 810 YDSLQLAHKC 820 ILNSFYGYVM 830 RKGARWYSME 840 MAGIVCFTGA 850 NIITQARELI 860 EQIGRPLELD 870 TDGIWCVLPN 880 SFPENFVFKT 890 TNVKKPKVTI 900 SYPGAMLNIM 910 VKEGFTNDQY 920 QELAEPSSLT 930 YVTRSENSIF 940 FEVDGPYLAM 950 ILPASKEEGK 960 KLKKRYAVFN 970 EDGSLAELKG 980 FEVKRRGELQ 990 LIKIFQSSVF 1000 EAFLKGSTLE 1010 EVYGSVAKVA 1020 DYWLDVLYSK 1030 AANMPDSELF 1040 ELISENRSMS 1050 RKLEDYGEQK 1060 STSISTAKRL 1070 AEFLGDQMVK 1080 DAGLSCRYII 1090 SRKPEGSPVT 1100 ERAIPLAIFQ 1110 AEPTVRKHFL 1120 RKWLKSSSLQ 1130 DFDIRAILDW 1140 DYYIERLGSA 1150 IQKIITIPAA 1160 LQQVKNPVPR 1170 VKHPDWLHKK 1180 LLEKNDVYKQ 1190 KKISELFTLE 1200 GRRQVTMAEA 1210 SEDSPRPSAP 1220 DMEDFGLVKL 1230 PHPAAPVTVK 1240 RKRVLWESQE 1250 ESQDLTPTVP 1260 WQEILGQPPA 1270 LGTSQEEWLV 1280 WLRFHKKKWQ 1290 LQARQRLARR 1300 KRQRLESAEG 1310 VLRPGAIRDG 1320 PATGLGSFLR 1330 RTARSILDLP 1340 WQIVQISETS 1350 QAGLFRLWAL 1360 VGSDLHCIRL 1370 SIPRVFYVNQ 1380 RVAKAEEGAS 1390 YRKVNRVLPR 1400 SNMVYNLYEY 1410 SVPEDMYQEH 1420 INEINAELSA 1430 PDIEGVYETQ 1440 VPLLFRALVH 1450 LGCVCVVNKQ 1460 LVRHLSGWEA 1470 ETFALEHLEM 1480 RSLAQFSYLE 1490 PGSIRHIYLY 1500 HHAQAHKALF 1510 GIFIPSQRRA 1520 SVFVLDTVRS 1530 NQMPSLGALY 1540 SAEHGLLLEK 1550 VGPELLPPPK 1560 HTFEVRAETD 1570 LKTICRAIQR 1580 FLLAYKEERR 1590 GPTLIAVQSS 1600 WELKRLASEI 1610 PVLEEFPLVP 1620 ICVADKINYG 1630 VLDWQRHGAR 1640 RMIRHYLNLD 1650 TCLSQAFEMS 1660 RYFHIPIGNL 1670 PEDISTFGSD 1680 LFFARHLQRH 1690 NHLLWLSPTA 1700 RPDLGGKEAD 1710 DNCLVMEFDD 1720 QATVEINSSG 1730 CYSTVCVELD 1740 LQNLAVNTIL 1750 QSHHVNDMEG 1760 ADSMGISFDV 1770 IQQASLEDMI 1780 TGGQAASAPA 1790 SYDETALCSN 1800 TFRILKSMVV 1810 GWVKEITQYH 1820 NIYADNQVMH 1830 FYRWLRSPSS 1840 LLHDPALHRT 1850 LHNMMKKLFL 1860 QLIAEFKRLG 1870 SSVIYANFNR 1880 IILCTKKRRV 1890 EDAIAYVEYI 1900 TSSIHSKETF 1910 HSLTISFSRC 1920 WEFLLWMDPS 1930 NYGGIKGKVS 1940 SRIHCGLQDS 1950 QKAGGAEDEQ 1960 ENEDDEEERD 1970 GEEEEEAEES 1980 NVEDLLENNW 1990 NILQFLPQAA 2000 SCQNYFLMIV 2010 SAYIVAVYHC 2020 MKDGLRRSAP 2030 GSTPVRRRGA 2040 SQLSQEAEGA 2050 VGALPGMITF 2060 SQDYVANELT 2070 QSFFTITQKI 2080 QKKVTGSRNS 2090 TELSEMFPVL 2100 PGSHLLLNNP 2110 ALEFIKYVCK 2120 VLSLDTNITN 2130 QVNKLNRDLL 2140 RLVDVGEFSE 2150 EAQFRDPCRS 2160 YVLPEVICRS 2170 CNFCRDLDLC 2180 KDSSFSEDGA 2190 VLPQWLCSNC 2200 QAPYDSSAIE 2210 MTLVEVLQKK 2220 LMAFTLQDLV 2230 CLKCRGVKET 2240 SMPVYCSCAG 2250 DFALTIHTQV 2260 FMEQIGIFRN 2270 IAQHYGMSYL 2280 LETLEWLLQK NPQLGH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0008622 epsilon DNA polymerase complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0051539 4 iron, 4 sulfur cluster binding
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003887 DNA-directed DNA polymerase activity
Molecular Function GO:0000166 nucleotide binding
Molecular Function GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006287 base-excision repair, gap-filling
Biological Process GO:0006260 DNA replication
Biological Process GO:0045004 DNA replication proofreading
Biological Process GO:0000731 DNA synthesis involved in DNA repair
Biological Process GO:0006261 DNA-templated DNA replication
Biological Process GO:0048568 embryonic organ development
Biological Process GO:0000082 G1/S transition of mitotic cell cycle
Biological Process GO:0006272 leading strand elongation
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0006297 nucleotide-excision repair, DNA gap filling

Reference

PMID: N/A