Search Results
Overview
| Uniprot ID | Q07936 |
|---|---|
| Protein Name | Annexin A2 |
| Gene Name | Anxa2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 148 | QEINRVYKEMYKTDL |
| 152 | RVYKEMYKTDLEKDI |
| 157 | MYKTDLEKDIISDTS |
| 169 | DTSGEFRKLLVALAK |
| 176 | KLLVALAKGKRAEDG |
| 204 | ELYDAGVKRKGTDVP |
| 206 | YDAGVKRKGTDVPKW |
| 227 | RSVCHLQKVFERYKS |
| 233 | QKVFERYKSYSPYDM |
| 279 | DRLYDSMKGKGTRDK |
| 281 | LYDSMKGKGTRDKVL |
| 302 | RSEVDMLKIRSEFKR |
| 313 | EFKRKYGKSLYYFIQ |
| 324 | YFIQQDTKGDYQKAL |
| 47 | LNIETAIKTKGVDEV |
| 49 | IETAIKTKGVDEVTI |
| 81 | AYQRRTKKELPSAMK |
Function
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (By similarity). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (By similarity)
Protein Sequence
10
MSTVHEILCK
20
LSLEGDHSTP
30
PSAYGSVKPY
40
TNFDAERDAL
50
NIETAIKTKG
60
VDEVTIVNIL
70
TNRSNAQRQD
80
IAFAYQRRTK
90
KELPSAMKSA
100
LSGHLETVML
110
GLLKTPAQYD
120
ASELKASMKG
130
LGTDEDSLIE
140
IICSRTNQEL
150
QEINRVYKEM
160
YKTDLEKDII
170
SDTSGEFRKL
180
LVALAKGKRA
190
EDGSVIDYEL
200
IDQDARELYD
210
AGVKRKGTDV
220
PKWISIMTER
230
SVCHLQKVFE
240
RYKSYSPYDM
250
LESIRKEVKG
260
DLENAFLNLV
270
QCIQNKPLYF
280
ADRLYDSMKG
290
KGTRDKVLIR
300
IMVSRSEVDM
310
LKIRSEFKRK
320
YGKSLYYFIQ
330
QDTKGDYQKA
LLYLCGGDD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1990665 | AnxA2-p11 complex |
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0001533 | cornified envelope |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0070382 | exocytic vesicle |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031902 | late endosome membrane |
| Cellular Component | GO:0005811 | lipid droplet |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0044354 | macropinosome |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0035749 | myelin sheath adaxonal region |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:1990667 | PCSK9-AnxA2 complex |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098797 | plasma membrane protein complex |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0090575 | RNA polymerase II transcription regulator complex |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0043220 | Schmidt-Lanterman incisure |
| Cellular Component | GO:0031982 | vesicle |
| Cellular Component | GO:0012506 | vesicle membrane |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0044730 | bone sialoprotein binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005544 | calcium-dependent phospholipid binding |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function | GO:0001786 | phosphatidylserine binding |
| Molecular Function | GO:0019834 | phospholipase A2 inhibitor activity |
| Molecular Function | GO:0002020 | protease binding |
| Molecular Function | GO:0044548 | S100 protein binding |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Molecular Function | GO:0031267 | small GTPase binding |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0007589 | body fluid secretion |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0007160 | cell-matrix adhesion |
| Biological Process | GO:0030199 | collagen fibril organization |
| Biological Process | GO:1904019 | epithelial cell apoptotic process |
| Biological Process | GO:0042730 | fibrinolysis |
| Biological Process | GO:0044794 | host-mediated activation of viral process |
| Biological Process | GO:0030324 | lung development |
| Biological Process | GO:0001765 | membrane raft assembly |
| Biological Process | GO:0042789 | mRNA transcription by RNA polymerase II |
| Biological Process | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process |
| Biological Process | GO:0002091 | negative regulation of receptor internalization |
| Biological Process | GO:0036035 | osteoclast development |
| Biological Process | GO:0048146 | positive regulation of fibroblast proliferation |
| Biological Process | GO:1905581 | positive regulation of low-density lipoprotein particle clearance |
| Biological Process | GO:0010756 | positive regulation of plasminogen activation |
| Biological Process | GO:0001934 | positive regulation of protein phosphorylation |
| Biological Process | GO:0001921 | positive regulation of receptor recycling |
| Biological Process | GO:1905602 | positive regulation of receptor-mediated endocytosis involved in cholesterol transport |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0044090 | positive regulation of vacuole organization |
| Biological Process | GO:0031340 | positive regulation of vesicle fusion |
| Biological Process | GO:1903902 | positive regulation of viral life cycle |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0051917 | regulation of fibrinolysis |
| Biological Process | GO:0050767 | regulation of neurogenesis |
| Biological Process | GO:0014823 | response to activity |
| Biological Process | GO:0097066 | response to thyroid hormone |
| Biological Process | GO:0006900 | vesicle budding from membrane |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.