Search Results

Overview

Uniprot IDQ07954
Protein NameProlow-density lipoprotein receptor-related protein 1
Gene NameLRP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1682 TSYDTNKKQINVARL
3053 GSNYTLLKQGLNNAV
520 GSDGKSCKKPEHELF

Function

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:1702392, PubMed:26142438). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553). Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (PubMed:9252371)

Protein Sequence

10 MLTPPLLLLL 20 PLLSALVAAA 30 IDAPKTCSPK 40 QFACRDQITC 50 ISKGWRCDGE 60 RDCPDGSDEA 70 PEICPQSKAQ 80 RCQPNEHNCL 90 GTELCVPMSR 100 LCNGVQDCMD 110 GSDEGPHCRE 120 LQGNCSRLGC 130 QHHCVPTLDG 140 PTCYCNSSFQ 150 LQADGKTCKD 160 FDECSVYGTC 170 SQLCTNTDGS 180 FICGCVEGYL 190 LQPDNRSCKA 200 KNEPVDRPPV 210 LLIANSQNIL 220 ATYLSGAQVS 230 TITPTSTRQT 240 TAMDFSYANE 250 TVCWVHVGDS 260 AAQTQLKCAR 270 MPGLKGFVDE 280 HTINISLSLH 290 HVEQMAIDWL 300 TGNFYFVDDI 310 DDRIFVCNRN 320 GDTCVTLLDL 330 ELYNPKGIAL 340 DPAMGKVFFT 350 DYGQIPKVER 360 CDMDGQNRTK 370 LVDSKIVFPH 380 GITLDLVSRL 390 VYWADAYLDY 400 IEVVDYEGKG 410 RQTIIQGILI 420 EHLYGLTVFE 430 NYLYATNSDN 440 ANAQQKTSVI 450 RVNRFNSTEY 460 QVVTRVDKGG 470 ALHIYHQRRQ 480 PRVRSHACEN 490 DQYGKPGGCS 500 DICLLANSHK 510 ARTCRCRSGF 520 SLGSDGKSCK 530 KPEHELFLVY 540 GKGRPGIIRG 550 MDMGAKVPDE 560 HMIPIENLMN 570 PRALDFHAET 580 GFIYFADTTS 590 YLIGRQKIDG 600 TERETILKDG 610 IHNVEGVAVD 620 WMGDNLYWTD 630 DGPKKTISVA 640 RLEKAAQTRK 650 TLIEGKMTHP 660 RAIVVDPLNG 670 WMYWTDWEED 680 PKDSRRGRLE 690 RAWMDGSHRD 700 IFVTSKTVLW 710 PNGLSLDIPA 720 GRLYWVDAFY 730 DRIETILLNG 740 TDRKIVYEGP 750 ELNHAFGLCH 760 HGNYLFWTEY 770 RSGSVYRLER 780 GVGGAPPTVT 790 LLRSERPPIF 800 EIRMYDAQQQ 810 QVGTNKCRVN 820 NGGCSSLCLA 830 TPGSRQCACA 840 EDQVLDADGV 850 TCLANPSYVP 860 PPQCQPGEFA 870 CANSRCIQER 880 WKCDGDNDCL 890 DNSDEAPALC 900 HQHTCPSDRF 910 KCENNRCIPN 920 RWLCDGDNDC 930 GNSEDESNAT 940 CSARTCPPNQ 950 FSCASGRCIP 960 ISWTCDLDDD 970 CGDRSDESAS 980 CAYPTCFPLT 990 QFTCNNGRCI 1000 NINWRCDNDN 1010 DCGDNSDEAG 1020 CSHSCSSTQF 1030 KCNSGRCIPE 1040 HWTCDGDNDC 1050 GDYSDETHAN 1060 CTNQATRPPG 1070 GCHTDEFQCR 1080 LDGLCIPLRW 1090 RCDGDTDCMD 1100 SSDEKSCEGV 1110 THVCDPSVKF 1120 GCKDSARCIS 1130 KAWVCDGDND 1140 CEDNSDEENC 1150 ESLACRPPSH 1160 PCANNTSVCL 1170 PPDKLCDGND 1180 DCGDGSDEGE 1190 LCDQCSLNNG 1200 GCSHNCSVAP 1210 GEGIVCSCPL 1220 GMELGPDNHT 1230 CQIQSYCAKH 1240 LKCSQKCDQN 1250 KFSVKCSCYE 1260 GWVLEPDGES 1270 CRSLDPFKPF 1280 IIFSNRHEIR 1290 RIDLHKGDYS 1300 VLVPGLRNTI 1310 ALDFHLSQSA 1320 LYWTDVVEDK 1330 IYRGKLLDNG 1340 ALTSFEVVIQ 1350 YGLATPEGLA 1360 VDWIAGNIYW 1370 VESNLDQIEV 1380 AKLDGTLRTT 1390 LLAGDIEHPR 1400 AIALDPRDGI 1410 LFWTDWDASL 1420 PRIEAASMSG 1430 AGRRTVHRET 1440 GSGGWPNGLT 1450 VDYLEKRILW 1460 IDARSDAIYS 1470 ARYDGSGHME 1480 VLRGHEFLSH 1490 PFAVTLYGGE 1500 VYWTDWRTNT 1510 LAKANKWTGH 1520 NVTVVQRTNT 1530 QPFDLQVYHP 1540 SRQPMAPNPC 1550 EANGGQGPCS 1560 HLCLINYNRT 1570 VSCACPHLMK 1580 LHKDNTTCYE 1590 FKKFLLYARQ 1600 MEIRGVDLDA 1610 PYYNYIISFT 1620 VPDIDNVTVL 1630 DYDAREQRVY 1640 WSDVRTQAIK 1650 RAFINGTGVE 1660 TVVSADLPNA 1670 HGLAVDWVSR 1680 NLFWTSYDTN 1690 KKQINVARLD 1700 GSFKNAVVQG 1710 LEQPHGLVVH 1720 PLRGKLYWTD 1730 GDNISMANMD 1740 GSNRTLLFSG 1750 QKGPVGLAID 1760 FPESKLYWIS 1770 SGNHTINRCN 1780 LDGSGLEVID 1790 AMRSQLGKAT 1800 ALAIMGDKLW 1810 WADQVSEKMG 1820 TCSKADGSGS 1830 VVLRNSTTLV 1840 MHMKVYDESI 1850 QLDHKGTNPC 1860 SVNNGDCSQL 1870 CLPTSETTRS 1880 CMCTAGYSLR 1890 SGQQACEGVG 1900 SFLLYSVHEG 1910 IRGIPLDPND 1920 KSDALVPVSG 1930 TSLAVGIDFH 1940 AENDTIYWVD 1950 MGLSTISRAK 1960 RDQTWREDVV 1970 TNGIGRVEGI 1980 AVDWIAGNIY 1990 WTDQGFDVIE 2000 VARLNGSFRY 2010 VVISQGLDKP 2020 RAITVHPEKG 2030 YLFWTEWGQY 2040 PRIERSRLDG 2050 TERVVLVNVS 2060 ISWPNGISVD 2070 YQDGKLYWCD 2080 ARTDKIERID 2090 LETGENREVV 2100 LSSNNMDMFS 2110 VSVFEDFIYW 2120 SDRTHANGSI 2130 KRGSKDNATD 2140 SVPLRTGIGV 2150 QLKDIKVFNR 2160 DRQKGTNVCA 2170 VANGGCQQLC 2180 LYRGRGQRAC 2190 ACAHGMLAED 2200 GASCREYAGY 2210 LLYSERTILK 2220 SIHLSDERNL 2230 NAPVQPFEDP 2240 EHMKNVIALA 2250 FDYRAGTSPG 2260 TPNRIFFSDI 2270 HFGNIQQIND 2280 DGSRRITIVE 2290 NVGSVEGLAY 2300 HRGWDTLYWT 2310 SYTTSTITRH 2320 TVDQTRPGAF 2330 ERETVITMSG 2340 DDHPRAFVLD 2350 ECQNLMFWTN 2360 WNEQHPSIMR 2370 AALSGANVLT 2380 LIEKDIRTPN 2390 GLAIDHRAEK 2400 LYFSDATLDK 2410 IERCEYDGSH 2420 RYVILKSEPV 2430 HPFGLAVYGE 2440 HIFWTDWVRR 2450 AVQRANKHVG 2460 SNMKLLRVDI 2470 PQQPMGIIAV 2480 ANDTNSCELS 2490 PCRINNGGCQ 2500 DLCLLTHQGH 2510 VNCSCRGGRI 2520 LQDDLTCRAV 2530 NSSCRAQDEF 2540 ECANGECINF 2550 SLTCDGVPHC 2560 KDKSDEKPSY 2570 CNSRRCKKTF 2580 RQCSNGRCVS 2590 NMLWCNGADD 2600 CGDGSDEIPC 2610 NKTACGVGEF 2620 RCRDGTCIGN 2630 SSRCNQFVDC 2640 EDASDEMNCS 2650 ATDCSSYFRL 2660 GVKGVLFQPC 2670 ERTSLCYAPS 2680 WVCDGANDCG 2690 DYSDERDCPG 2700 VKRPRCPLNY 2710 FACPSGRCIP 2720 MSWTCDKEDD 2730 CEHGEDETHC 2740 NKFCSEAQFE 2750 CQNHRCISKQ 2760 WLCDGSDDCG 2770 DGSDEAAHCE 2780 GKTCGPSSFS 2790 CPGTHVCVPE 2800 RWLCDGDKDC 2810 ADGADESIAA 2820 GCLYNSTCDD 2830 REFMCQNRQC 2840 IPKHFVCDHD 2850 RDCADGSDES 2860 PECEYPTCGP 2870 SEFRCANGRC 2880 LSSRQWECDG 2890 ENDCHDQSDE 2900 APKNPHCTSQ 2910 EHKCNASSQF 2920 LCSSGRCVAE 2930 ALLCNGQDDC 2940 GDSSDERGCH 2950 INECLSRKLS 2960 GCSQDCEDLK 2970 IGFKCRCRPG 2980 FRLKDDGRTC 2990 ADVDECSTTF 3000 PCSQRCINTH 3010 GSYKCLCVEG 3020 YAPRGGDPHS 3030 CKAVTDEEPF 3040 LIFANRYYLR 3050 KLNLDGSNYT 3060 LLKQGLNNAV 3070 ALDFDYREQM 3080 IYWTDVTTQG 3090 SMIRRMHLNG 3100 SNVQVLHRTG 3110 LSNPDGLAVD 3120 WVGGNLYWCD 3130 KGRDTIEVSK 3140 LNGAYRTVLV 3150 SSGLREPRAL 3160 VVDVQNGYLY 3170 WTDWGDHSLI 3180 GRIGMDGSSR 3190 SVIVDTKITW 3200 PNGLTLDYVT 3210 ERIYWADARE 3220 DYIEFASLDG 3230 SNRHVVLSQD 3240 IPHIFALTLF 3250 EDYVYWTDWE 3260 TKSINRAHKT 3270 TGTNKTLLIS 3280 TLHRPMDLHV 3290 FHALRQPDVP 3300 NHPCKVNNGG 3310 CSNLCLLSPG 3320 GGHKCACPTN 3330 FYLGSDGRTC 3340 VSNCTASQFV 3350 CKNDKCIPFW 3360 WKCDTEDDCG 3370 DHSDEPPDCP 3380 EFKCRPGQFQ 3390 CSTGICTNPA 3400 FICDGDNDCQ 3410 DNSDEANCDI 3420 HVCLPSQFKC 3430 TNTNRCIPGI 3440 FRCNGQDNCG 3450 DGEDERDCPE 3460 VTCAPNQFQC 3470 SITKRCIPRV 3480 WVCDRDNDCV 3490 DGSDEPANCT 3500 QMTCGVDEFR 3510 CKDSGRCIPA 3520 RWKCDGEDDC 3530 GDGSDEPKEE 3540 CDERTCEPYQ 3550 FRCKNNRCVP 3560 GRWQCDYDND 3570 CGDNSDEESC 3580 TPRPCSESEF 3590 SCANGRCIAG 3600 RWKCDGDHDC 3610 ADGSDEKDCT 3620 PRCDMDQFQC 3630 KSGHCIPLRW 3640 RCDADADCMD 3650 GSDEEACGTG 3660 VRTCPLDEFQ 3670 CNNTLCKPLA 3680 WKCDGEDDCG 3690 DNSDENPEEC 3700 ARFVCPPNRP 3710 FRCKNDRVCL 3720 WIGRQCDGTD 3730 NCGDGTDEED 3740 CEPPTAHTTH 3750 CKDKKEFLCR 3760 NQRCLSSSLR 3770 CNMFDDCGDG 3780 SDEEDCSIDP 3790 KLTSCATNAS 3800 ICGDEARCVR 3810 TEKAAYCACR 3820 SGFHTVPGQP 3830 GCQDINECLR 3840 FGTCSQLCNN 3850 TKGGHLCSCA 3860 RNFMKTHNTC 3870 KAEGSEYQVL 3880 YIADDNEIRS 3890 LFPGHPHSAY 3900 EQAFQGDESV 3910 RIDAMDVHVK 3920 AGRVYWTNWH 3930 TGTISYRSLP 3940 PAAPPTTSNR 3950 HRRQIDRGVT 3960 HLNISGLKMP 3970 RGIAIDWVAG 3980 NVYWTDSGRD 3990 VIEVAQMKGE 4000 NRKTLISGMI 4010 DEPHAIVVDP 4020 LRGTMYWSDW 4030 GNHPKIETAA 4040 MDGTLRETLV 4050 QDNIQWPTGL 4060 AVDYHNERLY 4070 WADAKLSVIG 4080 SIRLNGTDPI 4090 VAADSKRGLS 4100 HPFSIDVFED 4110 YIYGVTYINN 4120 RVFKIHKFGH 4130 SPLVNLTGGL 4140 SHASDVVLYH 4150 QHKQPEVTNP 4160 CDRKKCEWLC 4170 LLSPSGPVCT 4180 CPNGKRLDNG 4190 TCVPVPSPTP 4200 PPDAPRPGTC 4210 NLQCFNGGSC 4220 FLNARRQPKC 4230 RCQPRYTGDK 4240 CELDQCWEHC 4250 RNGGTCAASP 4260 SGMPTCRCPT 4270 GFTGPKCTQQ 4280 VCAGYCANNS 4290 TCTVNQGNQP 4300 QCRCLPGFLG 4310 DRCQYRQCSG 4320 YCENFGTCQM 4330 AADGSRQCRC 4340 TAYFEGSRCE 4350 VNKCSRCLEG 4360 ACVVNKQSGD 4370 VTCNCTDGRV 4380 APSCLTCVGH 4390 CSNGGSCTMN 4400 SKMMPECQCP 4410 PHMTGPRCEE 4420 HVFSQQQPGH 4430 IASILIPLLL 4440 LLLLVLVAGV 4450 VFWYKRRVQG 4460 AKGFQHQRMT 4470 NGAMNVEIGN 4480 PTYKMYEGGE 4490 PDDVGGLLDA 4500 DFALDPDKPT 4510 NFTNPVYATL 4520 YMGGHGSRHS 4530 LASTDEKREL 4540 LGRGPEDEIG DPLA

Gene Ontology

Classification GO ID Description
Molecular Function GO:0005044 scavenger receptor activity
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0005905 clathrin-coated pit
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005769 early endosome
Cellular Component GO:0030666 endocytic vesicle membrane
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0005815 microtubule organizing center
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098797 plasma membrane protein complex
Cellular Component GO:0043235 receptor complex
Molecular Function GO:0016964 alpha-2 macroglobulin receptor activity
Molecular Function GO:0001540 amyloid-beta binding
Molecular Function GO:0034185 apolipoprotein binding
Molecular Function GO:0030226 apolipoprotein receptor activity
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0038024 cargo receptor activity
Molecular Function GO:0032050 clathrin heavy chain binding
Molecular Function GO:0043395 heparan sulfate proteoglycan binding
Molecular Function GO:0070325 lipoprotein particle receptor binding
Molecular Function GO:0005041 low-density lipoprotein particle receptor activity
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0038023 signaling receptor activity
Molecular Function GO:0001618 virus receptor activity
Biological Process GO:0097242 amyloid-beta clearance
Biological Process GO:0150094 amyloid-beta clearance by cellular catabolic process
Biological Process GO:0150093 amyloid-beta clearance by transcytosis
Biological Process GO:0035909 aorta morphogenesis
Biological Process GO:0043277 apoptotic cell clearance
Biological Process GO:0002265 astrocyte activation involved in immune response
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:0007167 enzyme-linked receptor protein signaling pathway
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0042953 lipoprotein transport
Biological Process GO:0007041 lysosomal transport
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway
Biological Process GO:0060392 negative regulation of SMAD protein signal transduction
Biological Process GO:0014912 negative regulation of smooth muscle cell migration
Biological Process GO:0030178 negative regulation of Wnt signaling pathway
Biological Process GO:0006909 phagocytosis
Biological Process GO:1900223 positive regulation of amyloid-beta clearance
Biological Process GO:0010875 positive regulation of cholesterol efflux
Biological Process GO:0045807 positive regulation of endocytosis
Biological Process GO:0032370 positive regulation of lipid transport
Biological Process GO:1905167 positive regulation of lysosomal protein catabolic process
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:1903064 positive regulation of reverse cholesterol transport
Biological Process GO:1904300 positive regulation of transcytosis
Biological Process GO:0031623 receptor internalization
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0032956 regulation of actin cytoskeleton organization
Biological Process GO:0010715 regulation of extracellular matrix disassembly
Biological Process GO:1903053 regulation of extracellular matrix organization
Biological Process GO:0001523 retinoid metabolic process
Biological Process GO:0045056 transcytosis
Biological Process GO:0150104 transport across blood-brain barrier

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.