Search Results
Overview
| Uniprot ID | Q07954 |
|---|---|
| Protein Name | Prolow-density lipoprotein receptor-related protein 1 |
| Gene Name | LRP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1682 | TSYDTNKKQINVARL |
| 3053 | GSNYTLLKQGLNNAV |
| 520 | GSDGKSCKKPEHELF |
Function
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:1702392, PubMed:26142438). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553). Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (PubMed:9252371)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0005044 | scavenger receptor activity |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005905 | clathrin-coated pit |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0030666 | endocytic vesicle membrane |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005815 | microtubule organizing center |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098797 | plasma membrane protein complex |
| Cellular Component | GO:0043235 | receptor complex |
| Molecular Function | GO:0016964 | alpha-2 macroglobulin receptor activity |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0034185 | apolipoprotein binding |
| Molecular Function | GO:0030226 | apolipoprotein receptor activity |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0038024 | cargo receptor activity |
| Molecular Function | GO:0032050 | clathrin heavy chain binding |
| Molecular Function | GO:0043395 | heparan sulfate proteoglycan binding |
| Molecular Function | GO:0070325 | lipoprotein particle receptor binding |
| Molecular Function | GO:0005041 | low-density lipoprotein particle receptor activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0038023 | signaling receptor activity |
| Molecular Function | GO:0001618 | virus receptor activity |
| Biological Process | GO:0097242 | amyloid-beta clearance |
| Biological Process | GO:0150094 | amyloid-beta clearance by cellular catabolic process |
| Biological Process | GO:0150093 | amyloid-beta clearance by transcytosis |
| Biological Process | GO:0035909 | aorta morphogenesis |
| Biological Process | GO:0043277 | apoptotic cell clearance |
| Biological Process | GO:0002265 | astrocyte activation involved in immune response |
| Biological Process | GO:1904646 | cellular response to amyloid-beta |
| Biological Process | GO:0007167 | enzyme-linked receptor protein signaling pathway |
| Biological Process | GO:0006629 | lipid metabolic process |
| Biological Process | GO:0042953 | lipoprotein transport |
| Biological Process | GO:0007041 | lysosomal transport |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:2000587 | negative regulation of platelet-derived growth factor receptor-beta signaling pathway |
| Biological Process | GO:0060392 | negative regulation of SMAD protein signal transduction |
| Biological Process | GO:0014912 | negative regulation of smooth muscle cell migration |
| Biological Process | GO:0030178 | negative regulation of Wnt signaling pathway |
| Biological Process | GO:0006909 | phagocytosis |
| Biological Process | GO:1900223 | positive regulation of amyloid-beta clearance |
| Biological Process | GO:0010875 | positive regulation of cholesterol efflux |
| Biological Process | GO:0045807 | positive regulation of endocytosis |
| Biological Process | GO:0032370 | positive regulation of lipid transport |
| Biological Process | GO:1905167 | positive regulation of lysosomal protein catabolic process |
| Biological Process | GO:1903078 | positive regulation of protein localization to plasma membrane |
| Biological Process | GO:1903064 | positive regulation of reverse cholesterol transport |
| Biological Process | GO:1904300 | positive regulation of transcytosis |
| Biological Process | GO:0031623 | receptor internalization |
| Biological Process | GO:0006898 | receptor-mediated endocytosis |
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Biological Process | GO:0010715 | regulation of extracellular matrix disassembly |
| Biological Process | GO:1903053 | regulation of extracellular matrix organization |
| Biological Process | GO:0001523 | retinoid metabolic process |
| Biological Process | GO:0045056 | transcytosis |
| Biological Process | GO:0150104 | transport across blood-brain barrier |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.