Search Results
Overview
| Uniprot ID | Q07960 |
|---|---|
| Protein Name | Rho GTPase-activating protein 1 |
| Gene Name | ARHGAP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 48 | FPKSDDSKSSSPELV |
Function
GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate
Protein Sequence
10
MDPLSELQDD
20
LTLDDTSEAL
30
NQLKLASIDE
40
KNWPSDEMPD
50
FPKSDDSKSS
60
SPELVTHLKW
70
DDPYYDIARH
80
QIVEVAGDDK
90
YGRKIIVFSA
100
CRMPPSHQLD
110
HSKLLGYLKH
120
TLDQYVESDY
130
TLLYLHHGLT
140
SDNKPSLSWL
150
RDAYREFDRK
160
YKKNIKALYI
170
VHPTMFIKTL
180
LILFKPLISF
190
KFGQKIFYVN
200
YLSELSEHVK
210
LEQLGIPRQV
220
LKYDDFLKST
230
QKSPATAPKP
240
MPPRPPLPNQ
250
QFGVSLQHLQ
260
EKNPEQEPIP
270
IVLRETVAYL
280
QAHALTTEGI
290
FRRSANTQVV
300
REVQQKYNMG
310
LPVDFDQYNE
320
LHLPAVILKT
330
FLRELPEPLL
340
TFDLYPHVVG
350
FLNIDESQRV
360
PATLQVLQTL
370
PEENYQVLRF
380
LTAFLVQISA
390
HSDQNKMTNT
400
NLAVVFGPNL
410
LWAKDAAITL
420
KAINPINTFT
430
KFLLDHQGEL
FPSPDPSGL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0001726 | ruffle |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Molecular Function | GO:0031267 | small GTPase binding |
| Biological Process | GO:0016197 | endosomal transport |
| Biological Process | GO:2001136 | negative regulation of endocytic recycling |
| Biological Process | GO:0051056 | regulation of small GTPase mediated signal transduction |
| Biological Process | GO:0007266 | Rho protein signal transduction |
| Biological Process | GO:0007264 | small GTPase-mediated signal transduction |
| Biological Process | GO:0033572 | transferrin transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.