Search Results
Overview
| Uniprot ID | Q08117 |
|---|---|
| Protein Name | TLE family member 5 |
| Gene Name | TLE5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 19 | SHLPQQLKFTTSDSC |
Function
Transcriptional corepressor. Acts as a dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development
Protein Sequence
10
MMFPQSRHSG
20
SSHLPQQLKF
30
TTSDSCDRIK
40
DEFQLLQAQY
50
HSLKLECDKL
60
ASEKSEMQRH
70
YVMYYEMSYG
80
LNIEMHKQAE
90
IVKRLNGICA
100
QVLPYLSQEH
110
QQQVLGAIER
120
AKQVTAPELN
130
SIIRQQLQAH
140
QLSQLQALAL
150
PLTPLPVGLQ
160
PPSLPAVSAG
170
TGLLSLSALG
180
SQAHLSKEDK
190
NGHDGDTHQE
DDGEKSD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0060761 | negative regulation of response to cytokine stimulus |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:2000210 | positive regulation of anoikis |
| Biological Process | GO:0070555 | response to interleukin-1 |
| Biological Process | GO:0016055 | Wnt signaling pathway |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.