Search Results

Overview

Uniprot ID	Q08170
Protein Name	Serine/arginine-rich splicing factor 4
Gene Name	SRSF4
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
95	YRRSGRDKYGPPTRT

Function

Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10

Protein Sequence

10 MPRVYIGRLS 20 YQARERDVER 30 FFKGYGKILE 40 VDLKNGYGFV 50 EFDDLRDADD 60 AVYELNGKDL 70 CGERVIVEHA 80 RGPRRDGSYG 90 SGRSGYGYRR 100 SGRDKYGPPT 110 RTEYRLIVEN 120 LSSRCSWQDL 130 KDYMRQAGEV 140 TYADAHKGRK 150 NEGVIEFVSY 160 SDMKRALEKL 170 DGTEVNGRKI 180 RLVEDKPGSR 190 RRRSYSRSRS 200 HSRSRSRSRH 210 SRKSRSRSGS 220 SKSSHSKSRS 230 RSRSGSRSRS 240 KSRSRSQSRS 250 RSKKEKSRSP 260 SKEKSRSRSH 270 SAGKSRSKSK 280 DQAEEKIQNN 290 DNVGKPKSRS 300 PSRHKSKSKS 310 RSRSQERRVE 320 EEKRGSVSRG 330 RSQEKSLRQS 340 RSRSRSKGGS 350 RSRSRSRSKS 360 KDKRKGRKRS 370 REESRSRSRS 380 RSKSERSRKR 390 GSKRDSKAGS 400 SKKKKKEDTD 410 RSQSRSPSRS 420 VSKEREHAKS 430 ESSQREGRGE 440 SENAGTNQET 450 RSRSRSNSKS 460 KPNLPSESRS 470 RSKSASKTRS 480 RSKSRSRSAS 490 RSPSRSRSRS HSRS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016607	nuclear speck
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:1990825	sequence-specific mRNA binding
Biological Process	GO:0006397	mRNA processing
Biological Process	GO:0048025	negative regulation of mRNA splicing, via spliceosome
Biological Process	GO:0000381	regulation of alternative mRNA splicing, via spliceosome
Biological Process	GO:0032868	response to insulin
Biological Process	GO:0008380	RNA splicing
Biological Process	GO:0000375	RNA splicing, via transesterification reactions

Reference

[1] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.