Overview
| Uniprot ID | Q08357 |
|---|
| Protein Name | Sodium-dependent phosphate transporter 2 |
|---|
| Gene Name | SLC20A2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 349 |
HVYHTVHKDSGLYKD |
Function
Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:12205090, PubMed:15955065, PubMed:16790504, PubMed:17494632, PubMed:22327515, PubMed:28722801, PubMed:30704756). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity)
Protein Sequence
10
MAMDEYLWMV
20
ILGFIIAFIL
30
AFSVGANDVA
40
NSFGTAVGSG
50
VVTLRQACIL
60
ASIFETTGSV
70
LLGAKVGETI
80
RKGIIDVNLY
90
NETVETLMAG
100
EVSAMVGSAV
110
WQLIASFLRL
120
PISGTHCIVG
130
STIGFSLVAI
140
GTKGVQWMEL
150
VKIVASWFIS
160
PLLSGFMSGL
170
LFVLIRIFIL
180
KKEDPVPNGL
190
RALPVFYAAT
200
IAINVFSIMY
210
TGAPVLGLVL
220
PMWAIALISF
230
GVALLFAFFV
240
WLFVCPWMRR
250
KITGKLQKEG
260
ALSRVSDESL
270
SKVQEAESPV
280
FKELPGAKAN
290
DDSTIPLTGA
300
AGETLGTSEG
310
TSAGSHPRAA
320
YGRALSMTHG
330
SVKSPISNGT
340
FGFDGHTRSD
350
GHVYHTVHKD
360
SGLYKDLLHK
370
IHIDRGPEEK
380
PAQESNYRLL
390
RRNNSYTCYT
400
AAICGLPVHA
410
TFRAADSSAP
420
EDSEKLVGDT
430
VSYSKKRLRY
440
DSYSSYCNAV
450
AEAEIEAEEG
460
GVEMKLASEL
470
ADPDQPREDP
480
AEEEKEEKDA
490
PEVHLLFHFL
500
QVLTACFGSF
510
AHGGNDVSNA
520
IGPLVALWLI
530
YKQGGVTQEA
540
ATPVWLLFYG
550
GVGICTGLWV
560
WGRRVIQTMG
570
KDLTPITPSS
580
GFTIELASAF
590
TVVIASNIGL
600
PVSTTHCKVG
610
SVVAVGWIRS
620
RKAVDWRLFR
630
NIFVAWFVTV
640
PVAGLFSAAV
650
MALLMYGILP
YV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0031526 |
brush border membrane |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005315 |
phosphate transmembrane transporter activity |
| Molecular Function |
GO:0038023 |
signaling receptor activity |
| Molecular Function |
GO:0005436 |
sodium:phosphate symporter activity |
| Molecular Function |
GO:0001618 |
virus receptor activity |
| Biological Process |
GO:0035435 |
phosphate ion transmembrane transport |
| Biological Process |
GO:0030501 |
positive regulation of bone mineralization |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.