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Overview

Uniprot IDQ08431
Protein NameLactadherin
Gene NameMFGE8
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
156 LASHEYLKAFKVAYS
180 HDVNKKHKEFVGNWN
355 WDNHSHKKNLFETPI

Function

Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction

Protein Sequence

10 MPRPRLLAAL 20 CGALLCAPSL 30 LVALDICSKN 40 PCHNGGLCEE 50 ISQEVRGDVF 60 PSYTCTCLKG 70 YAGNHCETKC 80 VEPLGLENGN 90 IANSQIAASS 100 VRVTFLGLQH 110 WVPELARLNR 120 AGMVNAWTPS 130 SNDDNPWIQV 140 NLLRRMWVTG 150 VVTQGASRLA 160 SHEYLKAFKV 170 AYSLNGHEFD 180 FIHDVNKKHK 190 EFVGNWNKNA 200 VHVNLFETPV 210 EAQYVRLYPT 220 SCHTACTLRF 230 ELLGCELNGC 240 ANPLGLKNNS 250 IPDKQITASS 260 SYKTWGLHLF 270 SWNPSYARLD 280 KQGNFNAWVA 290 GSYGNDQWLQ 300 VDLGSSKEVT 310 GIITQGARNF 320 GSVQFVASYK 330 VAYSNDSANW 340 TEYQDPRTGS 350 SKIFPGNWDN 360 HSHKKNLFET 370 PILARYVRIL 380 PVAWHNRIAL RLELLGC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0002080 acrosomal membrane
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0009897 external side of plasma membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:1903561 extracellular vesicle
Cellular Component GO:0016020 membrane
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0001786 phosphatidylserine binding
Biological Process GO:0001525 angiogenesis
Biological Process GO:0043277 apoptotic cell clearance
Biological Process GO:0007155 cell adhesion
Biological Process GO:0007338 single fertilization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.