Search Results
Overview
| Uniprot ID | Q08499 |
|---|---|
| Protein Name | 3',5'-cyclic-AMP phosphodiesterase 4D |
| Gene Name | PDE4D |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 369 | SQISGVKKLMHSSSL |
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes
Protein Sequence
10
MEAEGSSAPA
20
RAGSGEGSDS
30
AGGATLKAPK
40
HLWRHEQHHQ
50
YPLRQPQFRL
60
LHPHHHLPPP
70
PPPSPQPQPQ
80
CPLQPPPPPP
90
LPPPPPPPGA
100
ARGRYASSGA
110
TGRVRHRGYS
120
DTERYLYCRA
130
MDRTSYAVET
140
GHRPGLKKSR
150
MSWPSSFQGL
160
RRFDVDNGTS
170
AGRSPLDPMT
180
SPGSGLILQA
190
NFVHSQRRES
200
FLYRSDSDYD
210
LSPKSMSRNS
220
SIASDIHGDD
230
LIVTPFAQVL
240
ASLRTVRNNF
250
AALTNLQDRA
260
PSKRSPMCNQ
270
PSINKATITE
280
EAYQKLASET
290
LEELDWCLDQ
300
LETLQTRHSV
310
SEMASNKFKR
320
MLNRELTHLS
330
EMSRSGNQVS
340
EFISNTFLDK
350
QHEVEIPSPT
360
QKEKEKKKRP
370
MSQISGVKKL
380
MHSSSLTNSS
390
IPRFGVKTEQ
400
EDVLAKELED
410
VNKWGLHVFR
420
IAELSGNRPL
430
TVIMHTIFQE
440
RDLLKTFKIP
450
VDTLITYLMT
460
LEDHYHADVA
470
YHNNIHAADV
480
VQSTHVLLST
490
PALEAVFTDL
500
EILAAIFASA
510
IHDVDHPGVS
520
NQFLINTNSE
530
LALMYNDSSV
540
LENHHLAVGF
550
KLLQEENCDI
560
FQNLTKKQRQ
570
SLRKMVIDIV
580
LATDMSKHMN
590
LLADLKTMVE
600
TKKVTSSGVL
610
LLDNYSDRIQ
620
VLQNMVHCAD
630
LSNPTKPLQL
640
YRQWTDRIME
650
EFFRQGDRER
660
ERGMEISPMC
670
DKHNASVEKS
680
QVGFIDYIVH
690
PLWETWADLV
700
HPDAQDILDT
710
LEDNREWYQS
720
TIPQSPSPAP
730
DDPEEGRQGQ
740
TEKFQFELTL
750
EEDGESDTEK
760
DSGSQVEEDT
770
SCSDSKTLCT
780
QDSESTEIPL
790
DEQVEEEAVG
800
EEEESQPEAC
VIDDRSPDT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0034704 | calcium channel complex |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0005891 | voltage-gated calcium channel complex |
| Molecular Function | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity |
| Molecular Function | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity |
| Molecular Function | GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0031698 | beta-2 adrenergic receptor binding |
| Molecular Function | GO:0005246 | calcium channel regulator activity |
| Molecular Function | GO:0030552 | cAMP binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:1901363 | heterocyclic compound binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Molecular Function | GO:0030545 | signaling receptor regulator activity |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0071875 | adrenergic receptor signaling pathway |
| Biological Process | GO:0006198 | cAMP catabolic process |
| Biological Process | GO:0071320 | cellular response to cAMP |
| Biological Process | GO:0071872 | cellular response to epinephrine stimulus |
| Biological Process | GO:0061028 | establishment of endothelial barrier |
| Biological Process | GO:0106072 | negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0141162 | negative regulation of cAMP/PKA signal transduction |
| Biological Process | GO:0045822 | negative regulation of heart contraction |
| Biological Process | GO:1901898 | negative regulation of relaxation of cardiac muscle |
| Biological Process | GO:0010460 | positive regulation of heart rate |
| Biological Process | GO:0032743 | positive regulation of interleukin-2 production |
| Biological Process | GO:0032754 | positive regulation of interleukin-5 production |
| Biological Process | GO:0032729 | positive regulation of type II interferon production |
| Biological Process | GO:1902514 | regulation of calcium ion transmembrane transport via high voltage-gated calcium channel |
| Biological Process | GO:0086004 | regulation of cardiac muscle cell contraction |
| Biological Process | GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction |
| Biological Process | GO:0002027 | regulation of heart rate |
| Biological Process | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| Biological Process | GO:0050852 | T cell receptor signaling pathway |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.