Overview
| Uniprot ID | Q08722 |
|---|
| Protein Name | Leukocyte surface antigen CD47 |
|---|
| Gene Name | CD47 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 304 |
KTIQPPRKAVEEPLN |
Function
Adhesive protein that mediates cell-to-cell interactions (PubMed:11509594, PubMed:15383453). Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (PubMed:19004835, PubMed:7691831, PubMed:8550562). Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation (PubMed:11509594, PubMed:15383453, PubMed:19004835, PubMed:27742621, PubMed:32679764, PubMed:7691831, PubMed:8550562). Plays a role in modulating pulmonary endothelin EDN1 signaling (PubMed:27742621). Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (PubMed:11509594). Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (PubMed:15383453). Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (By similarity). Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (PubMed:32679764). In response to THBS1, negatively modulates wound healing (By similarity). Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). May play a role in membrane transport and/or integrin dependent signal transduction (PubMed:7691831). May prevent premature elimination of red blood cells (By similarity)
Protein Sequence
10
MWPLVAALLL
20
GSACCGSAQL
30
LFNKTKSVEF
40
TFCNDTVVIP
50
CFVTNMEAQN
60
TTEVYVKWKF
70
KGRDIYTFDG
80
ALNKSTVPTD
90
FSSAKIEVSQ
100
LLKGDASLKM
110
DKSDAVSHTG
120
NYTCEVTELT
130
REGETIIELK
140
YRVVSWFSPN
150
ENILIVIFPI
160
FAILLFWGQF
170
GIKTLKYRSG
180
GMDEKTIALL
190
VAGLVITVIV
200
IVGAILFVPG
210
EYSLKNATGL
220
GLIVTSTGIL
230
ILLHYYVFST
240
AIGLTSFVIA
250
ILVIQVIAYI
260
LAVVGLSLCI
270
AACIPMHGPL
280
LISGLSILAL
290
AQLLGLVYMK
300
FVASNQKTIQ
310
PPRKAVEEPL
320
NAFKESKGMM
NDE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0035579 |
specific granule membrane |
| Cellular Component |
GO:0070821 |
tertiary granule membrane |
| Molecular Function |
GO:0098632 |
cell-cell adhesion mediator activity |
| Molecular Function |
GO:0070051 |
fibrinogen binding |
| Molecular Function |
GO:0086080 |
protein binding involved in heterotypic cell-cell adhesion |
| Molecular Function |
GO:0070053 |
thrombospondin receptor activity |
| Biological Process |
GO:0001525 |
angiogenesis |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:1904669 |
ATP export |
| Biological Process |
GO:0016477 |
cell migration |
| Biological Process |
GO:0071347 |
cellular response to interleukin-1 |
| Biological Process |
GO:0071349 |
cellular response to interleukin-12 |
| Biological Process |
GO:0071346 |
cellular response to type II interferon |
| Biological Process |
GO:0006954 |
inflammatory response |
| Biological Process |
GO:0007229 |
integrin-mediated signaling pathway |
| Biological Process |
GO:0050765 |
negative regulation of phagocytosis |
| Biological Process |
GO:0008284 |
positive regulation of cell population proliferation |
| Biological Process |
GO:0022409 |
positive regulation of cell-cell adhesion |
| Biological Process |
GO:0050729 |
positive regulation of inflammatory response |
| Biological Process |
GO:2000439 |
positive regulation of monocyte extravasation |
| Biological Process |
GO:0050766 |
positive regulation of phagocytosis |
| Biological Process |
GO:0051496 |
positive regulation of stress fiber assembly |
| Biological Process |
GO:0050870 |
positive regulation of T cell activation |
| Biological Process |
GO:0060368 |
regulation of Fc receptor mediated stimulatory signaling pathway |
| Biological Process |
GO:0032653 |
regulation of interleukin-10 production |
| Biological Process |
GO:0032655 |
regulation of interleukin-12 production |
| Biological Process |
GO:0032675 |
regulation of interleukin-6 production |
| Biological Process |
GO:0045428 |
regulation of nitric oxide biosynthetic process |
| Biological Process |
GO:0032680 |
regulation of tumor necrosis factor production |
| Biological Process |
GO:0032649 |
regulation of type II interferon production |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.