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Overview

Uniprot IDQ08999
Protein NameRetinoblastoma-like protein 2
Gene NameRBL2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
933 VYRSVLIKGKRKRRN

Function

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor

Protein Sequence

10 MPSGGDQSPP 20 PPPPPPAAAA 30 SDEEEEDDGE 40 AEDAAPPAES 50 PTPQIQQRFD 60 ELCSRLNMDE 70 AARAEAWDSY 80 RSMSESYTLE 90 GNDLHWLACA 100 LYVACRKSVP 110 TVSKGTVEGN 120 YVSLTRILKC 130 SEQSLIEFFN 140 KMKKWEDMAN 150 LPPHFRERTE 160 RLERNFTVSA 170 VIFKKYEPIF 180 QDIFKYPQEE 190 QPRQQRGRKQ 200 RRQPCTVSEI 210 FHFCWVLFIY 220 AKGNFPMISD 230 DLVNSYHLLL 240 CALDLVYGNA 250 LQCSNRKELV 260 NPNFKGLSED 270 FHAKDSKPSS 280 DPPCIIEKLC 290 SLHDGLVLEA 300 KGIKEHFWKP 310 YIRKLYEKKL 320 LKGKEENLTG 330 FLEPGNFGES 340 FKAINKAYEE 350 YVLSVGNLDE 360 RIFLGEDAEE 370 EIGTLSRCLN 380 AGSGTETAER 390 VQMKNILQQH 400 FDKSKALRIS 410 TPLTGVRYIK 420 ENSPCVTPVS 430 TATHSLSRLH 440 TMLTGLRNAP 450 SEKLEQILRT 460 CSRDPTQAIA 470 NRLKEMFEIY 480 SQHFQPDEDF 490 SNCAKEIASK 500 HFRFAEMLYY 510 KVLESVIEQE 520 QKRLGDMDLS 530 GILEQDAFHR 540 SLLACCLEVV 550 TFSYKPPGNF 560 PFITEIFDVP 570 LYHFYKVIEV 580 FIRAEDGLCR 590 EVVKHLNQIE 600 EQILDHLAWK 610 PESPLWEKIR 620 DNENRVPTCE 630 EVMPPQNLER 640 ADEICIAGSP 650 LTPRRVTEVR 660 ADTGGLGRSI 670 TSPTTLYDRY 680 SSPPASTTRR 690 RLFVENDSPS 700 DGGTPGRMPP 710 QPLVNAVPVQ 720 NVSGETVSVT 730 PVPGQTLVTM 740 ATATVTANNG 750 QTVTIPVQGI 760 ANENGGITFF 770 PVQVNVGGQA 780 QAVTGSIQPL 790 SAQALAGSLS 800 SQQVTGTTLQ 810 VPGQVAIQQI 820 SPGGQQQKQG 830 QSVTSSSNRP 840 RKTSSLSLFF 850 RKVYHLAAVR 860 LRDLCAKLDI 870 SDELRKKIWT 880 CFEFSIIQCP 890 ELMMDRHLDQ 900 LLMCAIYVMA 910 KVTKEDKSFQ 920 NIMRCYRTQP 930 QARSQVYRSV 940 LIKGKRKRRN 950 SGSSDSRSHQ 960 NSPTELNKDR 970 TSRDSSPVMR 980 SSSTLPVPQP 990 SSAPPTPTRL 1000 TGANSDMEEE 1010 ERGDLIQFYN 1020 NIYIKQIKTF 1030 AMKYSQANMD 1040 APPLSPYPFV 1050 RTGSPRRIQL 1060 SQNHPVYISP 1070 HKNETMLSPR 1080 EKIFYYFSNS 1090 PSKRLREINS 1100 MIRTGETPTK 1110 KRGILLEDGS 1120 ESPAKRICPE 1130 NHSALLRRLQ DVANDRGSH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:1990841 promoter-specific chromatin binding
Molecular Function GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
Biological Process GO:0030154 cell differentiation
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0043550 regulation of lipid kinase activity
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.