Overview
| Uniprot ID | Q08AD1 |
|---|
| Protein Name | Calmodulin-regulated spectrin-associated protein 2 |
|---|
| Gene Name | CAMSAP2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 231 |
LVPARYRKEQTLLKQ |
Function
Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242)
Protein Sequence
10
MGDAADPREM
20
RKTFIVPAIK
30
PFDHYDFSRA
40
KIACNLAWLV
50
AKAFGTENVP
60
EELQEPFYTD
70
QYDQEHIKPP
80
VVNLLLSAEL
90
YCRAGSLILK
100
SDAAKPLLGH
110
DAVIQALAQK
120
GLYVTDQEKL
130
VTERDLHKKP
140
IQMSAHLAMI
150
DTLMMAYTVE
160
MVSIEKVIAC
170
AQQYSAFFQA
180
TDLPYDIEDA
190
VMYWINKVNE
200
HLKDIMEQEQ
210
KLKEHHTVEA
220
PGGQKSPSKW
230
FWKLVPARYR
240
KEQTLLKQLP
250
CIPLVENLLK
260
DGTDGCALAA
270
LIHFYCPDVV
280
RLEDICLKET
290
MSLADSLYNL
300
QLIQEFCQEY
310
LNQCCHFTLE
320
DMLYAASSIK
330
SNYLVFMAEL
340
FWWFEVVKPS
350
FVQPRVVRPQ
360
GAEPVKDMPS
370
IPVLNAAKRN
380
VLDSSSDFPS
390
SGEGATFTQS
400
HHHLPSRYSR
410
PQAHSSASGG
420
IRRSSSMSYV
430
DGFIGTWPKE
440
KRSSVHGVSF
450
DISFDKEDSV
460
QRSTPNRGIT
470
RSISNEGLTL
480
NNSHVSKHIR
490
KNLSFKPING
500
EEEAESIEEE
510
LNIDSHSDLK
520
SCVPLNTNEL
530
NSNENIHYKL
540
PNGALQNRIL
550
LDEFGNQIET
560
PSIEEALQII
570
HDTEKSPHTP
580
QPDQIANGFF
590
LHSQEMSILN
600
SNIKLNQSSP
610
DNVTDTKGAL
620
SPITDNTEVD
630
TGIHVPSEDI
640
PETMDEDSSL
650
RDYTVSLDSD
660
MDDASKFLQD
670
YDIRTGNTRE
680
ALSPCPSTVS
690
TKSQPGSSAS
700
SSSGVKMTSF
710
AEQKFRKLNH
720
TDGKSSGSSS
730
QKTTPEGSEL
740
NIPHVVAWAQ
750
IPEETGLPQG
760
RDTTQLLASE
770
MVHLRMKLEE
780
KRRAIEAQKK
790
KMEAAFTKQR
800
QKMGRTAFLT
810
VVKKKGDGIS
820
PLREEAAGAE
830
DEKVYTDRAK
840
EKESQKTDGQ
850
RSKSLADIKE
860
SMENPQAKWL
870
KSPTTPIDPE
880
KQWNLASPSE
890
ETLNEGEILE
900
YTKSIEKLNS
910
SLHFLQQEMQ
920
RLSLQQEMLM
930
QMREQQSWVI
940
SPPQPSPQKQ
950
IRDFKPSKQA
960
GLSSAIAPFS
970
SDSPRPTHPS
980
PQSSNRKSAS
990
FSVKSQRTPR
1000
PNELKITPLN
1010
RTLTPPRSVD
1020
SLPRLRRFSP
1030
SQVPIQTRSF
1040
VCFGDDGEPQ
1050
LKESKPKEEV
1060
KKEELESKGT
1070
LEQRGHNPEE
1080
KEIKPFESTV
1090
SEVLSLPVTE
1100
TVCLTPNEDQ
1110
LNQPTEPPPK
1120
PVFPPTAPKN
1130
VNLIEVSLSD
1140
LKPPEKADVP
1150
VEKYDGESDK
1160
EQFDDDQKVC
1170
CGFFFKDDQK
1180
AENDMAMKRA
1190
ALLEKRLRRE
1200
KETQLRKQQL
1210
EAEMEHKKEE
1220
TRRKTEEERQ
1230
KKEDERARRE
1240
FIRQEYMRRK
1250
QLKLMEDMDT
1260
VIKPRPQVVK
1270
QKKQRPKSIH
1280
RDHIESPKTP
1290
IKGPPVSSLS
1300
LASLNTGDNE
1310
SVHSGKRTPR
1320
SESVEGFLSP
1330
SRCGSRNGEK
1340
DWENASTTSS
1350
VASGTEYTGP
1360
KLYKEPSAKS
1370
NKHIIQNALA
1380
HCCLAGKVNE
1390
GQKKKILEEM
1400
EKSDANNFLI
1410
LFRDSGCQFR
1420
SLYTYCPETE
1430
EINKLTGIGP
1440
KSITKKMIEG
1450
LYKYNSDRKQ
1460
FSHIPAKTLS
1470
ASVDAITIHS
1480
HLWQTKRPVT
PKKLLPTKA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0036064 |
ciliary basal body |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:1990752 |
microtubule end |
| Molecular Function |
GO:0005516 |
calmodulin binding |
| Molecular Function |
GO:0051011 |
microtubule minus-end binding |
| Molecular Function |
GO:0030507 |
spectrin binding |
| Biological Process |
GO:0061564 |
axon development |
| Biological Process |
GO:0031122 |
cytoplasmic microtubule organization |
| Biological Process |
GO:0000226 |
microtubule cytoskeleton organization |
| Biological Process |
GO:0007026 |
negative regulation of microtubule depolymerization |
| Biological Process |
GO:0050773 |
regulation of dendrite development |
| Biological Process |
GO:1903358 |
regulation of Golgi organization |
| Biological Process |
GO:0031113 |
regulation of microtubule polymerization |
| Biological Process |
GO:0033043 |
regulation of organelle organization |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.