Search Results

Overview

Uniprot IDQ08AH1
Protein NameAcyl-coenzyme A synthetase ACSM1, mitochondrial
Gene NameACSM1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
148 ATILLKAKDILYRLQ
158 LYRLQLSKAKGIVTI
185 QCPSLKTKLLVSDHS
204 LDFRSLVKSASPEHT
237 TGFPKMAKHSHGLAL
441 GDPEKTAKVECGDFY
549 APYKYPRKVEFVSEL
563 LPKTITGKIERKELR

Function

Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:10434065). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10434065). Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (By similarity). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (By similarity)

Protein Sequence

10 MQWLMRFRTL 20 WGIHKSFHNI 30 HPAPSQLRCR 40 SLSEFGAPRW 50 NDYEVPEEFN 60 FASYVLDYWA 70 QKEKEGKRGP 80 NPAFWWVNGQ 90 GDEVKWSFRE 100 MGDLTRRVAN 110 VFTQTCGLQQ 120 GDHLALMLPR 130 VPEWWLVAVG 140 CMRTGIIFIP 150 ATILLKAKDI 160 LYRLQLSKAK 170 GIVTIDALAS 180 EVDSIASQCP 190 SLKTKLLVSD 200 HSREGWLDFR 210 SLVKSASPEH 220 TCVKSKTLDP 230 MVIFFTSGTT 240 GFPKMAKHSH 250 GLALQPSFPG 260 SRKLRSLKTS 270 DVSWCLSDSG 280 WIVATIWTLV 290 EPWTAGCTVF 300 IHHLPQFDTK 310 VIIQTLLKYP 320 INHFWGVSSI 330 YRMILQQDFT 340 SIRFPALEHC 350 YTGGEVVLPK 360 DQEEWKRRTG 370 LLLYENYGQS 380 ETGLICATYW 390 GMKIKPGFMG 400 KATPPYDVQV 410 IDDKGSILPP 420 NTEGNIGIRI 430 KPVRPVSLFM 440 CYEGDPEKTA 450 KVECGDFYNT 460 GDRGKMDEEG 470 YICFLGRSDD 480 IINASGYRIG 490 PAEVESALVE 500 HPAVAESAVV 510 GSPDPIRGEV 520 VKAFIVLTPQ 530 FLSHDKDQLT 540 KELQQHVKSV 550 TAPYKYPRKV 560 EFVSELPKTI 570 TGKIERKELR KKETGQM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0072562 blood microparticle
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0018858 benzoate-CoA ligase activity
Molecular Function GO:0016405 CoA-ligase activity
Molecular Function GO:0102391 decanoate-CoA ligase activity
Molecular Function GO:0015645 fatty acid ligase activity
Molecular Function GO:0004321 fatty-acyl-CoA synthase activity
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0004467 long-chain fatty acid-CoA ligase activity
Molecular Function GO:0031956 medium-chain fatty acid-CoA ligase activity
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0006637 acyl-CoA metabolic process
Biological Process GO:0018874 benzoate metabolic process
Biological Process GO:0019605 butyrate metabolic process
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0015980 energy derivation by oxidation of organic compounds
Biological Process GO:0006633 fatty acid biosynthetic process
Biological Process GO:0019395 fatty acid oxidation
Biological Process GO:0006805 xenobiotic metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.