Search Results
Overview
| Uniprot ID | Q08AH3 |
|---|---|
| Protein Name | Acyl-coenzyme A synthetase ACSM2A, mitochondrial |
| Gene Name | ACSM2A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 180 | ECPSLRIKLLVSEKS |
| 186 | IKLLVSEKSCDGWLN |
| 195 | CDGWLNFKKLLNEAS |
| 196 | DGWLNFKKLLNEAST |
| 241 | SYSSLGLKAKMDAGW |
| 374 | GLTCMVSKTMKIKPG |
| 415 | GDIGIRVKPIRPIGI |
| 432 | GYVDNPDKTAANIRG |
| 450 | LLGDRGIKDEDGYFQ |
| 532 | KELQQHVKSVTAPYK |
| 539 | KSVTAPYKYPRKIEF |
| 543 | APYKYPRKIEFVLNL |
| 552 | EFVLNLPKTVTGKIQ |
| 557 | LPKTVTGKIQRAKLR |
| 569 | KLRDKEWKMSGKARA |
| 75 | ALWWVNGKGKELMWN |
| 77 | WWVNGKGKELMWNFR |
Function
Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (By similarity)
Protein Sequence
10
MHWLRKVQGL
20
CTLWGTQMSS
30
RTLYINSRQL
40
VSLQWGHQEV
50
PAKFNFASDV
60
LDHWADMEKA
70
GKRLPSPALW
80
WVNGKGKELM
90
WNFRELSENS
100
QQAANVLSGA
110
CGLQRGDRVA
120
VVLPRVPEWW
130
LVILGCIRAG
140
LIFMPGTIQM
150
KSTDILYRLQ
160
MSKAKAIVAG
170
DEVIQEVDTV
180
ASECPSLRIK
190
LLVSEKSCDG
200
WLNFKKLLNE
210
ASTTHHCVET
220
GSQEASAIYF
230
TSGTSGLPKM
240
AEHSYSSLGL
250
KAKMDAGWTG
260
LQASDIMWTI
270
SDTGWILNIL
280
CSLMEPWALG
290
ACTFVHLLPK
300
FDPLVILKTL
310
SSYPIKSMMG
320
APIVYRMLLQ
330
QDLSSYKFPH
340
LQNCVTVGES
350
LLPETLENWR
360
AQTGLDIRES
370
YGQTETGLTC
380
MVSKTMKIKP
390
GYMGTAASCY
400
DVQIIDDKGN
410
VLPPGTEGDI
420
GIRVKPIRPI
430
GIFSGYVDNP
440
DKTAANIRGD
450
FWLLGDRGIK
460
DEDGYFQFMG
470
RANDIINSSG
480
YRIGPSEVEN
490
ALMEHPAVVE
500
TAVISSPDPV
510
RGEVVKAFVV
520
LASQFLSHDP
530
EQLTKELQQH
540
VKSVTAPYKY
550
PRKIEFVLNL
560
PKTVTGKIQR
570
AKLRDKEWKM
SGKARAQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0018858 | benzoate-CoA ligase activity |
| Molecular Function | GO:0102391 | decanoate-CoA ligase activity |
| Molecular Function | GO:0015645 | fatty acid ligase activity |
| Molecular Function | GO:0004321 | fatty-acyl-CoA synthase activity |
| Molecular Function | GO:0031956 | medium-chain fatty acid-CoA ligase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006637 | acyl-CoA metabolic process |
| Biological Process | GO:0006633 | fatty acid biosynthetic process |
| Biological Process | GO:0042593 | glucose homeostasis |
| Biological Process | GO:0036112 | medium-chain fatty-acyl-CoA metabolic process |
| Biological Process | GO:0070328 | triglyceride homeostasis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.