Search Results

Overview

Uniprot IDQ08AM6
Protein NameProtein VAC14 homolog
Gene NameVAC14
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
423 MTRIAVLKWLYHLYI
740 KAAPKSQKADSPSID
761 HFEKVQNKHLEVRHQ

Function

Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P) (PubMed:33098764). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes

Protein Sequence

10 MNPEKDFAPL 20 TPNIVRALND 30 KLYEKRKVAA 40 LEIEKLVREF 50 VAQNNTVQIK 60 HVIQTLSQEF 70 ALSQHPHSRK 80 GGLIGLAACS 90 IALGKDSGLY 100 LKELIEPVLT 110 CFNDADSRLR 120 YYACEALYNI 130 VKVARGAVLP 140 HFNVLFDGLS 150 KLAADPDPNV 160 KSGSELLDRL 170 LKDIVTESNK 180 FDLVSFIPLL 190 RERIYSNNQY 200 ARQFIISWIL 210 VLESVPDINL 220 LDYLPEILDG 230 LFQILGDNGK 240 EIRKMCEVVL 250 GEFLKEIKKN 260 PSSVKFAEMA 270 NILVIHCQTT 280 DDLIQLTAMC 290 WMREFIQLAG 300 RVMLPYSSGI 310 LTAVLPCLAY 320 DDRKKSIKEV 330 ANVCNQSLMK 340 LVTPEDDELD 350 ELRPGQRQAE 360 PTPDDALPKQ 370 EGTASGGPDG 380 SCDSSFSSGI 390 SVFTAASTER 400 APVTLHLDGI 410 VQVLNCHLSD 420 TAIGMMTRIA 430 VLKWLYHLYI 440 KTPRKMFRHT 450 DSLFPILLQT 460 LSDESDEVIL 470 KDLEVLAEIA 480 SSPAGQTDDP 490 GPLDGPDLQA 500 SHSELQVPTP 510 GRAGLLNTSG 520 TKGLECSPST 530 PTMNSYFYKF 540 MINLLKRFSS 550 ERKLLEVRGP 560 FIIRQLCLLL 570 NAENIFHSMA 580 DILLREEDLK 590 FASTMVHALN 600 TILLTSTELF 610 QLRNQLKDLK 620 TLESQNLFCC 630 LYRSWCHNPV 640 TTVSLCFLTQ 650 NYRHAYDLIQ 660 KFGDLEVTVD 670 FLAEVDKLVQ 680 LIECPIFTYL 690 RLQLLDVKNN 700 PYLIKALYGL 710 LMLLPQSSAF 720 QLLSHRLQCV 730 PNPELLQTED 740 SLKAAPKSQK 750 ADSPSIDYAE 760 LLQHFEKVQN 770 KHLEVRHQRS 780 GRGDHLDRRV VL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031901 early endosome membrane
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0031902 late endosome membrane
Cellular Component GO:0070772 PAS complex
Cellular Component GO:0098830 presynaptic endosome
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0038023 signaling receptor activity
Biological Process GO:1903100 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process
Biological Process GO:0006661 phosphatidylinositol biosynthetic process
Biological Process GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization
Biological Process GO:0007165 signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.