Search Results

Overview

Uniprot IDQ09028
Protein NameHistone-binding protein RBBP4
Gene NameRBBP4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
4 ****MADKEAAFDDA

Function

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (PubMed:10866654). Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair (PubMed:8858152). Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (PubMed:9150135). Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:16428440, PubMed:28977666, PubMed:39460621). Component of the PRC2 complex, which promotes repression of homeotic genes during development (PubMed:29499137, PubMed:31959557). Component of the NURF (nucleosome remodeling factor) complex (PubMed:14609955, PubMed:15310751)

Protein Sequence

10 MADKEAAFDD 20 AVEERVINEE 30 YKIWKKNTPF 40 LYDLVMTHAL 50 EWPSLTAQWL 60 PDVTRPEGKD 70 FSIHRLVLGT 80 HTSDEQNHLV 90 IASVQLPNDD 100 AQFDASHYDS 110 EKGEFGGFGS 120 VSGKIEIEIK 130 INHEGEVNRA 140 RYMPQNPCII 150 ATKTPSSDVL 160 VFDYTKHPSK 170 PDPSGECNPD 180 LRLRGHQKEG 190 YGLSWNPNLS 200 GHLLSASDDH 210 TICLWDISAV 220 PKEGKVVDAK 230 TIFTGHTAVV 240 EDVSWHLLHE 250 SLFGSVADDQ 260 KLMIWDTRSN 270 NTSKPSHSVD 280 AHTAEVNCLS 290 FNPYSEFILA 300 TGSADKTVAL 310 WDLRNLKLKL 320 HSFESHKDEI 330 FQVQWSPHNE 340 TILASSGTDR 350 RLNVWDLSKI 360 GEEQSPEDAE 370 DGPPELLFIH 380 GGHTAKISDF 390 SWNPNEPWVI 400 CSVSEDNIMQ 410 VWQMAENIYN 420 DEDPEGSVDP EGQGS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0033186 CAF-1 complex
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000781 chromosome, telomeric region
Cellular Component GO:0035098 ESC/E(Z) complex
Cellular Component GO:0000118 histone deacetylase complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0016581 NuRD complex
Cellular Component GO:0016589 NURF complex
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0070822 Sin3-type complex
Molecular Function GO:0042393 histone binding
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Process GO:0007420 brain development
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006281 DNA repair
Biological Process GO:0006260 DNA replication
Biological Process GO:0006335 DNA replication-dependent chromatin assembly
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0031507 heterochromatin formation
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:1902455 negative regulation of stem cell population maintenance
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0006334 nucleosome assembly
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:1902459 positive regulation of stem cell population maintenance
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0042659 regulation of cell fate specification
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:2000736 regulation of stem cell differentiation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.