Search Results
Overview
| Uniprot ID | Q09167 |
|---|---|
| Protein Name | Serine/arginine-rich splicing factor 5 |
| Gene Name | Srsf5 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 25 | KDVERFFKGYGRIRD |
Function
May be required for progression through G1 and entry into S phase of cell growth. May play a regulatory role in pre-mRNA splicing. Autoregulates its own expression. Plays a role in constitutive splicing and can modulate the selection of alternative splice sites (By similarity). Could play an important role in development and differentiation in the spleen and thymus
Protein Sequence
10
MSGCRVFIGR
20
LNPAAREKDV
30
ERFFKGYGRI
40
RDIDLKRGFG
50
FVEFEDPRDA
60
DDAVYELDGK
70
ELCSERVTIE
80
HARARSRGGR
90
GRGRYSDRFS
100
SRRPRNDRRN
110
APPVRTENRL
120
IVENLSSRVS
130
WQDLKDFMRQ
140
AGEVTFADAH
150
RPKLNEGVVE
160
FASYGDLKNA
170
IEKLSGKEIN
180
GRKIKLIEGS
190
KRHRSRSRSR
200
SRTRSSSRSR
210
SRSRSRRSKS
220
YSRSRSRSRS
230
RSKSRSGSRS
240
PVPEKSQKRG
250
SSSRSKSPAS
260
VDRQRSRSRS
RSRSVDSGN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0043422 | protein kinase B binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0050733 | RS domain binding |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0001889 | liver development |
| Biological Process | GO:0097421 | liver regeneration |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0033120 | positive regulation of RNA splicing |
| Biological Process | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
| Biological Process | GO:0032868 | response to insulin |
| Biological Process | GO:0009611 | response to wounding |
| Biological Process | GO:0008380 | RNA splicing |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.