Search Results
Overview
| Uniprot ID | Q0II04 |
|---|---|
| Protein Name | Nebulette |
| Gene Name | Nebl |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 224 | EHAVGASKLSSQVKY |
Function
Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres. Isoform 2 might play a role in the assembly of focal adhesion (By similarity)
Protein Sequence
10
MKVPVSGDVK
20
EETEEENVEQ
30
EENQEAKVSL
40
KPVIEDLSME
50
LARKCTELIS
60
DIHYKEEYKK
70
SKDKCTFVTD
80
TPMLNHVKNI
90
GAFISEAKYK
100
GTIKADLSNC
110
LYKDMPATID
120
SVFAREVSQL
130
QSEVAYKQKH
140
EAEKGFSDYT
150
HMKEPPEVRR
160
AMEVNRHQSN
170
ISYRKDMQGT
180
HTYTAELDRP
190
DIKKATQISK
200
IISDAEYKKG
210
QGIVNKEPSV
220
IGRPDFEHAV
230
GASKLSSQVK
240
YKEKFDNEMK
250
EKSHHYNPLG
260
SAFFRQHQFA
270
AVLASDWEYK
280
RDFEENKGLY
290
HFDAEAPEHL
300
HHKGNATLQS
310
QVKYREEYEK
320
NKGKSMLEFV
330
ETPSYQSSKE
340
AQKMQSEKVY
350
KEDFEKEIKG
360
RSSLDLDKTP
370
AFLHVKHITN
380
LMREKEYKKD
390
LENEIKGKGM
400
ELSSEVLDIQ
410
RAKRASEMAS
420
EKDYKRDLET
430
EIKGKGMQVS
440
TDTLDVQRAK
450
RASEMASQVR
MV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001725 | stress fiber |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0008092 | cytoskeletal protein binding |
| Molecular Function | GO:0031005 | filamin binding |
| Molecular Function | GO:0005523 | tropomyosin binding |
| Biological Process | GO:0071691 | cardiac muscle thin filament assembly |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.