Overview
| Uniprot ID | Q0JRZ9 |
|---|
| Protein Name | F-BAR domain only protein 2 |
|---|
| Gene Name | FCHO2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 476 |
RPKLTSGKLSGINEI |
Function
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor
Protein Sequence
10
MVMAYFVENF
20
WGEKNSGFDV
30
LYHNMKHGQI
40
STKELADFVR
50
ERATIEEAYS
60
RSMTKLAKSA
70
SNYSQLGTFA
80
PVWDVFKTST
90
EKLANCHLDL
100
VRKLQELIKE
110
VQKYGEEQVK
120
SHKKTKEEVA
130
GTLEAVQTIQ
140
SITQALQKSK
150
ENYNAKCVEQ
160
ERLKKEGATQ
170
REIEKAAVKS
180
KKATDTYKLY
190
VEKYALAKAD
200
FEQKMTETAQ
210
KFQDIEETHL
220
IHIKEIIGSL
230
SNAIKEIHLQ
240
IGQVHEEFIN
250
NMANTTVESL
260
IQKFAESKGT
270
GKERPGLIEF
280
EECDTASAVE
290
GIKPRKRKTF
300
ALPGIIKKEK
310
DAESVECPDA
320
DSLNIPDVDE
330
EGYSIKPETN
340
QNDTKENHFY
350
SSSDSDSEDE
360
EPKKYRIEIK
370
PMHPNNSHHT
380
MASLDELKVS
390
IGNITLSPAI
400
SRHSPVQMNR
410
NLSNEELTKS
420
KPSAPPNEKG
430
TSDLLAWDPL
440
FGPSLDSSSS
450
SSLTSSSSAR
460
PTTPLSVGTI
470
VPPPRPASRP
480
KLTSGKLSGI
490
NEIPRPFSPP
500
VTSNTSPPPA
510
APLARAESSS
520
SISSSASLSA
530
ANTPTVGVSR
540
GPSPVSLGNQ
550
DTLPVAVALT
560
ESVNAYFKGA
570
DPTKCIVKIT
580
GDMTMSFPSG
590
IIKVFTSNPT
600
PAVLCFRVKN
610
ISRLEQILPN
620
AQLVFSDPSQ
630
CDSNTKDFWM
640
NMQAVTVYLK
650
KLSEQNPAAS
660
YYNVDVLKYQ
670
VSSNGIQSTP
680
LNLATYWKCS
690
ASTTDLRVDY
700
KYNPEAMVAP
710
SVLSNIQVVV
720
PVDGGVTNMQ
730
SLPPAIWNAE
740
QMKAFWKLSS
750
ISEKSENGGS
760
GSLRAKFDLS
770
EGPSKPTTLA
780
VQFLSEGSTL
790
SGVDFELVGT
800
GYRLSLIKKR
810
FATGRYLADC
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005905 |
clathrin-coated pit |
| Cellular Component |
GO:0030136 |
clathrin-coated vesicle |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0098793 |
presynapse |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0035091 |
phosphatidylinositol binding |
| Molecular Function |
GO:0005546 |
phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function |
GO:0001786 |
phosphatidylserine binding |
| Biological Process |
GO:0048268 |
clathrin coat assembly |
| Biological Process |
GO:0072583 |
clathrin-dependent endocytosis |
| Biological Process |
GO:0010324 |
membrane invagination |
| Biological Process |
GO:0072659 |
protein localization to plasma membrane |
| Biological Process |
GO:0048488 |
synaptic vesicle endocytosis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.