Search Results
Overview
| Uniprot ID | Q0PIT9 |
|---|---|
| Protein Name | NAD(P)H-hydrate epimerase |
| Gene Name | NAXE |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 148 | YYPKRPNKPLFTALV |
| 246 | ISLTAPKKSAAQFTG |
Function
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (By similarity)
Protein Sequence
10
MSGLRALLGL
20
GLPVAGSRLP
30
RVRVQAGACR
40
ARPTWWGPQR
50
LISGGRGDVE
60
GMASSAVKYL
70
SQEEAQAVDQ
80
ELFNEYQFSV
90
DQLMELAGLS
100
CATAIAKVYP
110
PTSLSRSPPT
120
VLVICGPGNN
130
GGDGLVCARH
140
LKLFGYHPTI
150
YYPKRPNKPL
160
FTALVTQCQK
170
MDIPFLDEMP
180
SEPTLIDELY
190
ELVVDAIFGF
200
SFKGEVREPF
210
RSILSVLNGL
220
TVPIASIDIP
230
SGWDVERGNS
240
GGIQPDLLIS
250
LTAPKKSAAQ
260
FTGRYHYLGG
270
RFVPPALEKK
280
YQLNLPPYPD
TECVYRLQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0052856 | NAD(P)HX epimerase activity |
| Molecular Function | GO:0000166 | nucleotide binding |
| Biological Process | GO:0006869 | lipid transport |
| Biological Process | GO:0031580 | membrane raft distribution |
| Biological Process | GO:0016525 | negative regulation of angiogenesis |
| Biological Process | GO:0046496 | nicotinamide nucleotide metabolic process |
| Biological Process | GO:0010874 | regulation of cholesterol efflux |
| Biological Process | GO:0002040 | sprouting angiogenesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.