Search Results
Overview
| Uniprot ID | Q0QF01 |
|---|---|
| Protein Name | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial |
| Gene Name | SDHA |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 167 | FSRTEDGKIYQRAFG |
| 179 | AFGGQSLKFGKGGQA |
| 538 | VLQEGCEKILRLYGD |
| 608 | VDEYDYSKPIQGQQK |
| 616 | PIQGQQKKPFQEHWR |
| 624 | PFQEHWRKHTLSYVD |
| 633 | TLSYVDVKTGKVSLE |
| 636 | YVDVKTGKVSLEYRP |
Function
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (Probable) (PubMed:15989954). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity). Can act as a tumor suppressor (By similarity)
Protein Sequence
10
MSGVRAVSRL
20
LRARRLALTW
30
AQPAASPIGA
40
RSFHFTVDGN
50
KRSSAKVSDA
60
ISTQYPVVDH
70
EFDAVVVGAG
80
GAGLRAAFGL
90
SEAGFNTACV
100
TKLFPTRSHT
110
VAAQGGINAA
120
LGNMEEDNWR
130
WHFYDTVKGS
140
DWLGDQDAIH
150
YMTEQAPASV
160
VELENYGMPF
170
SRTEDGKIYQ
180
RAFGGQSLKF
190
GKGGQAHRCC
200
CVADRTGHSL
210
LHTLYGRSLR
220
YDTSYFVEYF
230
ALDLLMENGE
240
CRGVIALCIE
250
DGSIHRIRAR
260
NTVVATGGYG
270
RTYFSCTSAH
280
TSTGDGTAMV
290
TRAGLPCQDL
300
EFVQFHPTGI
310
YGAGCLITEG
320
CRGEGGILIN
330
SQGERFMERY
340
APVAKDLASR
350
DVVSRSMTLE
360
IREGRGCGPE
370
KDHVYLQLHH
380
LPPEQLAVRL
390
PGISETAMIF
400
AGVDVTKEPI
410
PVLPTVHYNM
420
GGIPTNYKGQ
430
VLRHVNGQDQ
440
VVPGLYACGE
450
AACASVHGAN
460
RLGANSLLDL
470
VVFGRACALS
480
IAESCRPGDK
490
VPSIKPNAGE
500
ESVMNLDKLR
510
FANGTIRTSE
520
LRLSMQKSMQ
530
SHAAVFRVGS
540
VLQEGCEKIL
550
RLYGDLQHLK
560
TFDRGMVWNT
570
DLVETLELQN
580
LMLCALQTIY
590
GAEARKESRG
600
AHAREDFKER
610
VDEYDYSKPI
620
QGQQKKPFQE
630
HWRKHTLSYV
640
DVKTGKVSLE
650
YRPVIDKTLN
660
EADCATVPPA
IRSY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Molecular Function | GO:0008177 | succinate dehydrogenase (quinone) activity |
| Biological Process | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0006105 | succinate metabolic process |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0045273 | respiratory chain complex II (succinate dehydrogenase) |
| Molecular Function | GO:0009055 | electron transfer activity |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.