Search Results

Overview

Uniprot IDQ0VDD8
Protein NameDynein axonemal heavy chain 14
Gene NameDNAH14
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1226 FRFVLEGKEIRINMS
1762 KNPDKLTKIIQKLFV
3074 THGSASIKDYIHIIQ

Function

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity)

Protein Sequence

10 MGRRSQWIWA 20 MRCQMLVPVL 30 SLHIGLARAL 40 GCGCIASKIE 50 CLIRCNAPFP 60 LLDAVGSVAS 70 QELQSLTGTV 80 GVTSGAAAYP 90 RWNLARARAP 100 PHLPGTQDPL 110 RRVRDPTPIV 120 ASSPGRRRGS 130 WSGGYGQEAS 140 EPGVVGLCCA 150 VLPIHPSLAL 160 AGVGGPDLRR 170 FQEGPQRPSD 180 HGAAEKHMET 190 FIPIDLTTEN 200 QEMDKEETKT 210 KPRLLRYEEK 220 KYEDVKPLET 230 QPAEIAEKET 240 LEYKTVRTFS 250 ESLKSEKTEE 260 PKDDDVIRNI 270 IRLREKLGWQ 280 TILPQHSLKY 290 GSSKIAIQKI 300 TLKKPLEDDG 310 EFVYCLPRKS 320 PKSLYNPYDL 330 QVVSAHTAKH 340 CKEFWVITAS 350 FISKLDSSRT 360 YSLDEFCEEQ 370 LQQATQALKQ 380 LEDIRNKAIS 390 EMKSTFLKVA 400 EKNEIKEYFE 410 SKLSEDDTTH 420 FKLPKYRRLL 430 ETFFKFVMLV 440 DYIFQELIRQ 450 LMNTAVTLLL 460 ELFNGSAGMP 470 FSVEKKNENL 480 IRTFKDNSFP 490 TGKTTNDCEE 500 LVDNSKLHAI 510 SVQKSEVKTD 520 TDINEILNSV 530 EVGKDLRKTY 540 APIFEVNLCL 550 RIPAESDSSE 560 NSKENFHESD 570 QCPEECVMFE 580 DEMSENKDNC 590 VKKHSSEELL 600 PKAKKSKEIS 610 YNLEDIISAT 620 ITPLCQDPQL 630 SIFIDLVSIM 640 DLPNKTGSII 650 HYKEQTRWPD 660 CHILFETDPA 670 YQNIIVNLLT 680 IIGNSMGLVN 690 AYSHKFIKYC 700 TMTEKAKIMS 710 MKISSMGELT 720 SKEFEAILNR 730 FRNYFRHIVN 740 MAIEKRIGIF 750 NVVVESSLQQ 760 LECDPTEIEE 770 FLEHFIFLNA 780 ISSKISKLEK 790 EFLTMSQLYS 800 VAKHHQIHIS 810 EEQIAIFQVL 820 LLKFSQLKSS 830 MKLSKINKDT 840 AITKFRDNLE 850 ACISGLHVDV 860 GNLKAKIRTP 870 LLLCAGTQVS 880 TAMEMIQTLS 890 GEAASLTNKA 900 KAYSHYQDCF 910 SDSQSHMHSV 920 NVEEITQIVL 930 SEISDIEGDL 940 TLRKKLWEAQ 950 EEWKRASWEW 960 RNSSLQSIDV 970 ESVQRNVSKL 980 MHIISVLEKE 990 IYSIFIIPSI 1000 DDISAQLEES 1010 QVILATIKGS 1020 PHIGPIKSQI 1030 MFYNDCVKSF 1040 VSSYSREKLE 1050 KVHAGLMCHL 1060 EEVADLVVLD 1070 TSNSRTKAIL 1080 GALLILYVHC 1090 RDIVINLLLK 1100 NIFNAEDFEW 1110 TRHLQYKWNE 1120 KQKLCYVSQG 1130 NASFTYGYEY 1140 LGCTSRLVIT 1150 PLTDRCWLTL 1160 MEALHLNLGG 1170 CPAGPAGTGK 1180 TETVKDLAKC 1190 ALFAFKCNTA 1200 LIKLPNSLIV 1210 LTCFGLEKTV 1220 LVMNTVMSFR 1230 FVLEGKEIRI 1240 NMSCAVFITM 1250 NPRYGGGVEL 1260 PDNLKSLFRP 1270 VAMMVPHYQM 1280 IAEIILFSFG 1290 FKSANSLSGK 1300 LTNLYELARK 1310 QLSQQDHYNF 1320 GLRSLKIVLI 1330 MAGTKKREFK 1340 CDTSDSLSEA 1350 DETLIVIEAI 1360 REASLPKCPP 1370 EDVPLFENII 1380 GDIFPEVTVL 1390 KVNQLALEKV 1400 IYTATQQLGL 1410 QNWSSQKEKI 1420 IQFYNQLQVC 1430 VGVMLVGPTG 1440 GGKTTVRRIL 1450 EKALTLLPIA 1460 DFLSVAERKS 1470 ASKISERKGK 1480 VDICVLNPKC 1490 VTLSELYGQL 1500 DPNTMEWTDG 1510 LLSATIRSYV 1520 YFNTPKNTKK 1530 DIDLRLKSRI 1540 SDLSNVFKLD 1550 SSDTTETDDN 1560 IFEEIEKVVK 1570 IPENHNFDWQ 1580 WIILDGPVDT 1590 FWVENLNSVL 1600 DDTRTLCLAN 1610 SERIALTNKI 1620 RVIFEVDNLS 1630 QASPATVSRC 1640 AMVYMDPVDL 1650 GWEPYVKSWL 1660 LKTSKIISQS 1670 GVDCLEFMIK 1680 NSVTDGLQFI 1690 RNRQKFQPYP 1700 MEDITVVITL 1710 CRILDAFFDF 1720 MGKNGGFEQS 1730 DDLNDTSSKE 1740 ANSQRESVTF 1750 KDIEKRDENT 1760 WYPEKNPDKL 1770 TKIIQKLFVF 1780 AFTWAFGGAL 1790 NREDEHRENI 1800 PFCPSLEPDS 1810 LAKVTYDFDK 1820 LVHELFGNSS 1830 QVGINLPTGE 1840 CSIFGYFVDI 1850 EQCEFIPWSD 1860 LVPNDQTLIQ 1870 RDNPTKKPEV 1880 RTNKKLLKNN 1890 DHKGVVVSTI 1900 NFSTNVTAAK 1910 TKEMILKKLI 1920 RRTKDTLGAP 1930 KNNRILIFID 1940 DMNMPVSDMY 1950 GAQPPLELIR 1960 QLLDLGGVYD 1970 TEKNTWKNIQ 1980 DLSIVAACVP 1990 VVNDISPRLL 2000 KHFSMLVLPH 2010 PSQDILCTIF 2020 QIGIDGCGKK 2030 TCATLACYLT 2040 DNKLYRVPIS 2050 HKCAYIEFKE 2060 VFKKVFIHAG 2070 LKGKPTVLMV 2080 PNLNIEQDSF 2090 LEDLNYIISS 2100 GRIPDLFENV 2110 ELDSIAMKIR 2120 YLTEQSGHMD 2130 NRQSLLSFFQ 2140 KRIYKNLHIF 2150 VIMSPEGPSF 2160 RQNCRVYPSM 2170 ISSCTIDWYE 2180 RWPEEALLIV 2190 ANSFLKEKVN 2200 FENRENLKEK 2210 LAPTCVQIHK 2220 SMKDLNRKYF 2230 EETGRFYYTT 2240 PNSYLQFMET 2250 FAHILRAREE 2260 EMQTKRDRFH 2270 MGLSTILEAT 2280 TLVTEMQEEL 2290 LILGPQVEQK 2300 TKETETLMEK 2310 LRKDSQVVEK 2320 VQMLVKQDEE 2330 IVAEEVRIVE 2340 DYAQKTANEL 2350 KSVLPAFDKA 2360 IVALNALDKA 2370 DVAELRVYTR 2380 PPFLVLTVMN 2390 AVCILLQKKP 2400 NWATAKLLLS 2410 ETGFLKKLIN 2420 LDKDSIPDKV 2430 FVKLKKIVTL 2440 PDFNPHKISL 2450 VSVACCSLCQ 2460 WVIALNNYHE 2470 VQKVVGPKQI 2480 QVAEAQNVLK 2490 IARQRLAEKQ 2500 RGLQLISRWH 2510 NQGLPHGQYS 2520 VENAILIKNG 2530 QQWPLLIDPH 2540 RQAHKWIRQM 2550 EGSRLQKLSI 2560 EDSNYTKKIE 2570 NAMKTGGSVL 2580 LQSCQASTWR 2590 KKLYLSTEID 2600 NPHFLPSVYN 2610 FVTMINFTVT 2620 FQGLQDQLLS 2630 TVVTHEVPHL 2640 EDQRSKLLES 2650 ISLDAITLEE 2660 LEEKTLNLLQ 2670 KALGSILDDD 2680 KIVDTLRKSK 2690 MTSNEISKRI 2700 EATKKAESEI 2710 QAIRKNYLPI 2720 ATRGALLYFL 2730 VADLTQINYM 2740 YQFSLDWFHQ 2750 VFVSSVVSKS 2760 KEQEHSFKRE 2770 KVSPKEVHEF 2780 ISISKEPNLE 2790 NEKNLLDKHI 2800 KSAIDMLTKS 2810 IFKVVSSALF 2820 NEDKLCFSFR 2830 LCTVIMQNNA 2840 NGNLIQDDIG 2850 FLPEEEWNIF 2860 LYSGILINIK 2870 SALSQSRLTS 2880 TFEIGESQHL 2890 QWLSDSRWRQ 2900 CQYVSTHLEP 2910 FSLLCKSLLS 2920 NVSQWDTFKN 2930 SKAVYSLIST 2940 PFSSENASLE 2950 ENTKPPEEKH 2960 TFCLLLRAIN 2970 HTGTDLGPVG 2980 RGQWLTSTAC 2990 DRHTDVCSFS 3000 FALNDGVPDV 3010 EHVQDIFYGH 3020 CVDKYHVKVL 3030 RPESLNNSVR 3040 KFITEKMGNK 3050 YLQRTGVNLK 3060 DAYKGSNART 3070 PLILIQTHGS 3080 ASIKDYIHII 3090 QSLPDDDLPE 3100 VLGIHPEAIR 3110 SCWETQGEKF 3120 IENLIAMQPK 3130 TTTANLMIRP 3140 EQSKDELVME 3150 ILSDLLKRLP 3160 LTVEKEEIAV 3170 GTPSTLKSMM 3180 SSSIWESLSK 3190 NLKDHDPLIH 3200 CVLLTFLKQE 3210 IKRFDKLLFV 3220 IHKSLKDLQL 3230 AIKGEIILTQ 3240 ELEEIFNSFL 3250 NMRVPTLWQK 3260 HAYRSCKPLS 3270 SWIDDLIQRL 3280 NFFNTWAKVA 3290 YTAIQRRYMR 3300 FVTVWKQSIP 3310 STSQKCKHPE 3320 DSENNFFEGF 3330 PSRYWLPAFF 3340 FPQAFLAAVL 3350 QDYGRSRGIA 3360 VDALTFTHHV 3370 ISNTTDKDEK 3380 FSVFMPKKLN 3390 IVRRAFKGSA 3400 SSHTGVYIFG 3410 LFIEGARWNR 3420 EQKILEDSLP 3430 LEMCCDFPDI 3440 YFLPTKISTK 3450 TPNASNQTDS 3460 ELYAFECPVY 3470 QTPERSRILA 3480 TTGLPTNFLT 3490 SVYLSTKKPP 3500 SHWITMRVAL LCEKNEK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0097729 9+2 motile cilium
Cellular Component GO:0005930 axoneme
Cellular Component GO:0030286 dynein complex
Cellular Component GO:0005874 microtubule
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0045505 dynein intermediate chain binding
Molecular Function GO:0051959 dynein light intermediate chain binding
Molecular Function GO:0008569 minus-end-directed microtubule motor activity
Biological Process GO:0060294 cilium movement involved in cell motility

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.