Search Results
Overview
| Uniprot ID | Q0ZGT2 |
|---|---|
| Protein Name | Nexilin |
| Gene Name | NEXN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 187 | KTSGKMKKNFEDLEK |
Function
Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity
Protein Sequence
10
MNDISQKAEI
20
LLSSSKPVPK
30
TYVPKLGKGD
40
VKDKFEAMQR
50
AREERNQRRS
60
RDEKQRRKEQ
70
YIREREWNRR
80
KQEIKEMLAS
90
DDEEDVSSKV
100
EKAYVPKLTG
110
TVKGRFAEME
120
KQRQEEQRKR
130
TEEERKRRIE
140
QDMLEKRKIQ
150
RELAKRAEQI
160
EDINNTGTES
170
ASEEGDDSLL
180
ITVVPVKSYK
190
TSGKMKKNFE
200
DLEKEREEKE
210
RIKYEEDKRI
220
RYEEQRPSLK
230
EAKCLSLVMD
240
DEIESEAKKE
250
SLSPGKLKLT
260
FEELERQRQE
270
NRKKQAEEEA
280
RKRLEEEKRA
290
FEEARRQMVN
300
EDEENQDTAK
310
IFKGYRPGKL
320
KLSFEEMERQ
330
RREDEKRKAE
340
EEARRRIEEE
350
KKAFAEARRN
360
MVVDDDSPEM
370
YKTISQEFLT
380
PGKLEINFEE
390
LLKQKMEEEK
400
RRTEEERKHK
410
LEMEKQEFEQ
420
LRQEMGEEEE
430
ENETFGLSRE
440
YEELIKLKRS
450
GSIQAKNLKS
460
KFEKIGQLSE
470
KEIQKKIEEE
480
RARRRAIDLE
490
IKEREAENFH
500
EEDDVDVRPA
510
RKSEAPFTHK
520
VNMKARFEQM
530
AKAREEEEQR
540
RIEEQKLLRM
550
QFEQREIDAA
560
LQKKREEEEE
570
EEGSIMNGST
580
AEDEEQTRSG
590
APWFKKPLKN
600
TSVVDSEPVR
610
FTVKVTGEPK
620
PEITWWFEGE
630
ILQDGEDYQY
640
IERGETYCLY
650
LPETFPEDGG
660
EYMCKAVNNK
670
GSAASTCILT
IESKN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0098632 | cell-cell adhesion mediator activity |
| Molecular Function | GO:0008307 | structural constituent of muscle |
| Biological Process | GO:0007411 | axon guidance |
| Biological Process | GO:0070593 | dendrite self-avoidance |
| Biological Process | GO:0007156 | homophilic cell-cell adhesion |
| Biological Process | GO:0030334 | regulation of cell migration |
| Biological Process | GO:0051493 | regulation of cytoskeleton organization |
| Cellular Component | GO:0005912 | adherens junction |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.