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Overview

Uniprot IDQ10567
Protein NameAP-1 complex subunit beta-1
Gene NameAP1B1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
11 SKYFTTTKKGEIFEL
12 KYFTTTKKGEIFELK
545 KEVVLAEKPLISEET

Function

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes (PubMed:31630791). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules

Protein Sequence

10 MTDSKYFTTT 20 KKGEIFELKA 30 ELNSDKKEKK 40 KEAVKKVIAS 50 MTVGKDVSAL 60 FPDVVNCMQT 70 DNLELKKLVY 80 LYLMNYAKSQ 90 PDMAIMAVNT 100 FVKDCEDPNP 110 LIRALAVRTM 120 GCIRVDKITE 130 YLCEPLRKCL 140 KDEDPYVRKT 150 AAVCVAKLHD 160 INAQLVEDQG 170 FLDTLKDLIS 180 DSNPMVVANA 190 VAALSEIAES 200 HPSSNLLDLN 210 PQSINKLLTA 220 LNECTEWGQI 230 FILDCLANYM 240 PKDDREAQSI 250 CERVTPRLSH 260 ANSAVVLSAV 270 KVLMKFMEML 280 SKDLDYYGTL 290 LKKLAPPLVT 300 LLSAEPELQY 310 VALRNINLIV 320 QKRPEILKHE 330 MKVFFVKYND 340 PIYVKLEKLD 350 IMIRLASQAN 360 IAQVLAELKE 370 YATEVDVDFV 380 RKAVRAIGRC 390 AIKVEQSAER 400 CVSTLLDLIQ 410 TKVNYVVQEA 420 IVVIKDIFRK 430 YPNKYESVIA 440 TLCENLDSLD 450 EPEARAAMIW 460 IVGEYAERID 470 NADELLESFL 480 EGFHDESTQV 490 QLQLLTAIVK 500 LFLKKPTETQ 510 ELVQQVLSLA 520 TQDSDNPDLR 530 DRGYIYWRLL 540 STDPVAAKEV 550 VLAEKPLISE 560 ETDLIEPTLL 570 DELICYIGTL 580 ASVYHKPPSA 590 FVEGGRGVVH 600 KSLPPRTASS 610 ESAESPETAP 620 TGAPPGEQPD 630 VIPAQGDLLG 640 DLLNLDLGPP 650 VSGPPLATSS 660 VQMGAVDLLG 670 GGLDSLMGDE 680 PEGIGGTNFV 690 APPTAAVPAN 700 LGAPIGSGLS 710 DLFDLTSGVG 720 TLSGSYVAPK 730 AVWLPAMKAK 740 GLEISGTFTR 750 QVGSISMDLQ 760 LTNKALQVMT 770 DFAIQFNRNS 780 FGLAPAAPLQ 790 VHAPLSPNQT 800 VEISLPLSTV 810 GSVMKMEPLN 820 NLQVAVKNNI 830 DVFYFSTLYP 840 LHILFVEDGK 850 MDRQMFLATW 860 KDIPNENEAQ 870 FQIRDCPLNA 880 EAASSKLQSS 890 NIFTVAKRNV 900 EGQDMLYQSL 910 KLTNGIWVLA 920 ELRIQPGNPS 930 CTDLELSLKC 940 RAPEVSQHVY QAYETILKN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030131 clathrin adaptor complex
Cellular Component GO:0030665 clathrin-coated vesicle membrane
Cellular Component GO:0030659 cytoplasmic vesicle membrane
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005769 early endosome
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0008021 synaptic vesicle
Cellular Component GO:0032588 trans-Golgi network membrane
Molecular Function GO:0030276 clathrin binding
Molecular Function GO:0019901 protein kinase binding
Biological Process GO:0110010 basolateral protein secretion
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:1903232 melanosome assembly
Biological Process GO:0060155 platelet dense granule organization
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.