Search Results

Overview

Uniprot IDQ10570
Protein NameCleavage and polyadenylation specificity factor subunit 1
Gene NameCPSF1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1326 ATEGLSKKSVVWENK
420 DKEEPPSKKKRVDAT
912 KPKPSKKKAEGGGAE

Function

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (PubMed:14749727). May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity)

Protein Sequence

10 MYAVYKQAHP 20 PTGLEFSMYC 30 NFFNNSERNL 40 VVAGTSQLYV 50 YRLNRDAEAL 60 TKNDRSTEGK 70 AHREKLELAA 80 SFSFFGNVMS 90 MASVQLAGAK 100 RDALLLSFKD 110 AKLSVVEYDP 120 GTHDLKTLSL 130 HYFEEPELRD 140 GFVQNVHTPR 150 VRVDPDGRCA 160 AMLVYGTRLV 170 VLPFRRESLA 180 EEHEGLVGEG 190 QRSSFLPSYI 200 IDVRALDEKL 210 LNIIDLQFLH 220 GYYEPTLLIL 230 FEPNQTWPGR 240 VAVRQDTCSI 250 VAISLNITQK 260 VHPVIWSLTS 270 LPFDCTQALA 280 VPKPIGGVVV 290 FAVNSLLYLN 300 QSVPPYGVAL 310 NSLTTGTTAF 320 PLRTQEGVRI 330 TLDCAQATFI 340 SYDKMVISLK 350 GGEIYVLTLI 360 TDGMRSVRAF 370 HFDKAAASVL 380 TTSMVTMEPG 390 YLFLGSRLGN 400 SLLLKYTEKL 410 QEPPASAVRE 420 AADKEEPPSK 430 KKRVDATAGW 440 SAAGKSVPQD 450 EVDEIEVYGS 460 EAQSGTQLAT 470 YSFEVCDSIL 480 NIGPCANAAV 490 GEPAFLSEEF 500 QNSPEPDLEI 510 VVCSGHGKNG 520 ALSVLQKSIR 530 PQVVTTFELP 540 GCYDMWTVIA 550 PVRKEEEDNP 560 KGEGTEQEPS 570 TTPEADDDGR 580 RHGFLILSRE 590 DSTMILQTGQ 600 EIMELDTSGF 610 ATQGPTVFAG 620 NIGDNRYIVQ 630 VSPLGIRLLE 640 GVNQLHFIPV 650 DLGAPIVQCA 660 VADPYVVIMS 670 AEGHVTMFLL 680 KSDSYGGRHH 690 RLALHKPPLH 700 HQSKVITLCL 710 YRDLSGMFTT 720 ESRLGGARDE 730 LGGRSGPEAE 740 GLGSETSPTV 750 DDEEEMLYGD 760 SGSLFSPSKE 770 EARRSSQPPA 780 DRDPAPFRAE 790 PTHWCLLVRE 800 NGTMEIYQLP 810 DWRLVFLVKN 820 FPVGQRVLVD 830 SSFGQPTTQG 840 EARREEATRQ 850 GELPLVKEVL 860 LVALGSRQSR 870 PYLLVHVDQE 880 LLIYEAFPHD 890 SQLGQGNLKV 900 RFKKVPHNIN 910 FREKKPKPSK 920 KKAEGGGAEE 930 GAGARGRVAR 940 FRYFEDIYGY 950 SGVFICGPSP 960 HWLLVTGRGA 970 LRLHPMAIDG 980 PVDSFAPFHN 990 VNCPRGFLYF 1000 NRQGELRISV 1010 LPAYLSYDAP 1020 WPVRKIPLRC 1030 TAHYVAYHVE 1040 SKVYAVATST 1050 NTPCARIPRM 1060 TGEEKEFETI 1070 ERDERYIHPQ 1080 QEAFSIQLIS 1090 PVSWEAIPNA 1100 RIELQEWEHV 1110 TCMKTVSLRS 1120 EETVSGLKGY 1130 VAAGTCLMQG 1140 EEVTCRGRIL 1150 IMDVIEVVPE 1160 PGQPLTKNKF 1170 KVLYEKEQKG 1180 PVTALCHCNG 1190 HLVSAIGQKI 1200 FLWSLRASEL 1210 TGMAFIDTQL 1220 YIHQMISVKN 1230 FILAADVMKS 1240 ISLLRYQEES 1250 KTLSLVSRDA 1260 KPLEVYSVDF 1270 MVDNAQLGFL 1280 VSDRDRNLMV 1290 YMYLPEAKES 1300 FGGMRLLRRA 1310 DFHVGAHVNT 1320 FWRTPCRGAT 1330 EGLSKKSVVW 1340 ENKHITWFAT 1350 LDGGIGLLLP 1360 MQEKTYRRLL 1370 MLQNALTTML 1380 PHHAGLNPRA 1390 FRMLHVDRRT 1400 LQNAVRNVLD 1410 GELLNRYLYL 1420 STMERSELAK 1430 KIGTTPDIIL 1440 DDLLETDRVT AHF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0035925 mRNA 3'-UTR AU-rich region binding
Biological Process GO:0180012 co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway
Biological Process GO:0031124 mRNA 3'-end processing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.