Overview
| Uniprot ID | Q10758 |
|---|
| Protein Name | Keratin, type II cytoskeletal 8 |
|---|
| Gene Name | Krt8 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 158 |
LEALGQEKLKLEVEL |
| 295 |
ELQTLAGKHGDDLRR |
| 304 |
GDDLRRSKTEISEMN |
| 325 |
QAEIDALKGQRATLE |
| 347 |
QRGELAVKDANAKLE |
| 357 |
NAKLEDLKNALQKAK |
| 472 |
KIETRDGKLVSESSD |
Function
Structural component of intermediate filaments in simple epithelial cells. Together with its obligate type I partner KRT18, contributes to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to epithelial cells (PubMed:1691189). Also involved in maintaining epithelial integrity and protecting cells from non-mechanical stress, such as apoptosis (By similarity). Also required for ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement (By similarity). In striated muscle, together with KRT19, may contribute to linking the contractile apparatus to dystrophin at the costameres (PubMed:15247274)
Protein Sequence
10
MSVRVTQKSY
20
KMSTSGPRAF
30
SSRSFTSGPG
40
ARISSSSFSR
50
VGSSSSSFRG
60
SLGGFGGAGV
70
GGITAVTVNQ
80
SLLNPLKLEV
90
DPNIQAVRTQ
100
EKEQIKTLNN
110
KFASFIDKVR
120
FLEQQNKMLE
130
TKWSLLQQQK
140
TSRSNMDNMF
150
ESYINNLRRQ
160
LEALGQEKLK
170
LEVELGNMQG
180
LVEDFKNKYE
190
DEINKRTEME
200
NEFVLIKKDV
210
DEAYMNKVEL
220
ESRLEGLTDE
230
INFLRQIHEE
240
EIRELQSQIS
250
DTSVVLSMDN
260
SRSLDMDSII
270
AEVRAQYEEI
280
ANRSRAEAET
290
MYQIKYEELQ
300
TLAGKHGDDL
310
RRSKTEISEM
320
NRNISRLQAE
330
IDALKGQRAT
340
LEAAIADAEQ
350
RGELAVKDAN
360
AKLEDLKNAL
370
QKAKQDMARQ
380
LREYQELMNV
390
KLALDIEIAT
400
YRKLLEGEES
410
RLESGMQNMS
420
IHTKTTSGYA
430
GGLSSSYGGL
440
TSPGFSYGMS
450
SFQPGFGSVG
460
GSSTYSRTKA
470
VVVKKIETRD
480
GKLVSESSDI
MSK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016327 |
apicolateral plasma membrane |
| Cellular Component |
GO:0071944 |
cell periphery |
| Cellular Component |
GO:0005911 |
cell-cell junction |
| Cellular Component |
GO:0043034 |
costamere |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0016010 |
dystrophin-associated glycoprotein complex |
| Cellular Component |
GO:0005882 |
intermediate filament |
| Cellular Component |
GO:0045111 |
intermediate filament cytoskeleton |
| Cellular Component |
GO:0045095 |
keratin filament |
| Cellular Component |
GO:0016363 |
nuclear matrix |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0042383 |
sarcolemma |
| Cellular Component |
GO:0030018 |
Z disc |
| Molecular Function |
GO:0044877 |
protein-containing complex binding |
| Molecular Function |
GO:0097110 |
scaffold protein binding |
| Biological Process |
GO:0060706 |
cell differentiation involved in embryonic placenta development |
| Biological Process |
GO:0097191 |
extrinsic apoptotic signaling pathway |
| Biological Process |
GO:0097284 |
hepatocyte apoptotic process |
| Biological Process |
GO:0051599 |
response to hydrostatic pressure |
| Biological Process |
GO:0051707 |
response to other organism |
| Biological Process |
GO:0045214 |
sarcomere organization |
| Biological Process |
GO:0033209 |
tumor necrosis factor-mediated signaling pathway |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.