Search Results
Overview
| Uniprot ID | Q12765 |
|---|---|
| Protein Name | Secernin-1 |
| Gene Name | SCRN1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 18 | VAFPPRAKDGLVVFG |
Function
Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity)
Protein Sequence
10
MAAAPPSYCF
20
VAFPPRAKDG
30
LVVFGKNSAR
40
PRDEVQEVVY
50
FSAADHEPES
60
KVECTYISID
70
QVPRTYAIMI
80
SRPAWLWGAE
90
MGANEHGVCI
100
ANEAINTREP
110
AAEIEALLGM
120
DLVRLGLERG
130
ETAKEALDVI
140
VSLLEEHGQG
150
GNYFEDANSC
160
HSFQSAYLIV
170
DRDEAWVLET
180
IGKYWAAEKV
190
TEGVRCICSQ
200
LSLTTKMDAE
210
HPELRSYAQS
220
QGWWTGEGEF
230
NFSEVFSPVE
240
DHLDCGAGKD
250
SLEKQEESIT
260
VQTMMNTLRD
270
KASGVCIDSE
280
FFLTTASGVS
290
VLPQNRSSPC
300
IHYFTGTPDP
310
SRSIFKPFIF
320
VDDVKLVPKT
330
QSPCFGDDDP
340
AKKEPRFQEK
350
PDRRHELYKA
360
HEWARAIIES
370
DQEQGRKLRS
380
TMLELEKQGL
390
EAMEEILTSS
400
EPLDPAEVGD
410
LFYDCVDTEI
KFFK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0098793 | presynapse |
| Molecular Function | GO:0070004 | cysteine-type exopeptidase activity |
| Molecular Function | GO:0016805 | dipeptidase activity |
| Biological Process | GO:0006887 | exocytosis |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:0098693 | regulation of synaptic vesicle cycle |
| Cellular Component | GO:0031965 | nuclear membrane |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.