Search Results

Overview

Uniprot ID	Q12774
Protein Name	Rho guanine nucleotide exchange factor 5
Gene Name	ARHGEF5
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1060	SRGPAVEKHPGPSDT

Function

Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization (PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (PubMed:14662653). Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration (By similarity)

Protein Sequence

10 MEAEEAQRGA 20 SPPISAIEEF 30 SIIPEAPMRS 40 SQVSALGLEA 50 QEDEDPSYKW 60 REEHRLSATQ 70 QSELRDVCDY 80 AIETMPSFPK 90 EGSADVEPNQ 100 ESLVAEACDT 110 PEHWEAVPQS 120 LAGRQARTLA 130 PPELWACPIQ 140 SEHLDMAPFS 150 SDLGSEEEEV 160 EFWPGLTSLT 170 LGSGQAEEEE 180 ETSSDNSGQT 190 RYYSPCEEHP 200 AETNQNEGSE 210 SGTIRQGEEL 220 PPEELQESQG 230 LLHPQEVQVL 240 EEQGQQEAGF 250 RGEGTLREDV 260 CADGLLGEEQ 270 MIEQVNDEKG 280 EQKQKQEQVQ 290 DVMLGRQGER 300 MGLTGEPEGL 310 NDGEWEQEDM 320 ERKAQGQGGP 330 EQGEERKREL 340 QVPEENRADS 350 QDEKSQTFLG 360 KSEEVTGKQE 370 DHGIKEKGVP 380 VSGQEAKEPE 390 SWDGGRLGAV 400 GRARSREEEN 410 EHHGPSMPAL 420 IAPEDSPHCD 430 LFPGASYLMT 440 QIPGTQTESR 450 AEELSPAALS 460 PSLEPIRCSH 470 QPISLLGSFL 480 TEESPDKEID 490 QNSQQEESRL 500 RKGTVSSQGT 510 EVVFASASVT 520 PPRTPDSAPP 530 SPAEAYPITP 540 ASVSARPPVA 550 FPRRETSCAA 560 RAPETASAPL 570 SMDDPSPCGT 580 SEMCPAALYG 590 FPSTGTSPPR 600 PPANSTGTVQ 610 HLRSDSFPGS 620 HRTEQTPDLV 630 GMLLSYSHSE 640 LPQRPPKPAI 650 YSSVTPRRDR 660 RSGRDYSTVS 670 ASPTALSTLK 680 QDSQESISNL 690 ERPSSPPSIQ 700 PWVSPHNPAF 710 ATESPAYGSS 720 PSFVSMEDVR 730 IHEPLPPPPP 740 QRRDTHPSVV 750 ETDGHARVVV 760 PTLKQHSHPP 770 PLALGSGLHA 780 PHKGPLPQAS 790 DPAVARQHRP 800 LPSTPDSSHH 810 AQATPRWRYN 820 KPLPPTPDLP 830 QPHLPPISAP 840 GSSRIYRPLP 850 PLPIIDPPTE 860 PPPLPPKSRG 870 RSRSTRGGHM 880 NSGGHAKTRP 890 ACQDWTVPLP 900 ASAGRTSWPP 910 ATARSTESFT 920 STSRSKSEVS 930 PGMAFSNMTN 940 FLCPSSPTTP 950 WTPELQGPTS 960 KDEAGVSEHP 970 EAPAREPLRR 980 TTPQQGASGP 990 GRSPVGQARQ 1000 PEKPSHLHLE 1010 KASSWPHRRD 1020 SGRPPGDSSG 1030 QAVAPSEGAN 1040 KHKGWSRQGL 1050 RRPSILPEGS 1060 SDSRGPAVEK 1070 HPGPSDTVVF 1080 REKKPKEVMG 1090 GFSRRCSKLI 1100 NSSQLLYQEY 1110 SDVVLNKEIQ 1120 SQQRLESLSE 1130 TPGPSSPRQP 1140 RKALVSSESY 1150 LQRLSMASSG 1160 SLWQEIPVVR 1170 NSTVLLSMTH 1180 EDQKLQEVKF 1190 ELIVSEASYL 1200 RSLNIAVDHF 1210 QLSTSLRATL 1220 SNQEHQWLFS 1230 RLQDVRDVSA 1240 TFLSDLEENF 1250 ENNIFSFQVC 1260 DVVLNHAPDF 1270 RRVYLPYVTN 1280 QTYQERTFQS 1290 LMNSNSNFRE 1300 VLEKLESDPV 1310 CQRLSLKSFL 1320 ILPFQRITRL 1330 KLLLQNILKR 1340 TQPGSSEEAE 1350 ATKAHHALEQ 1360 LIRDCNNNVQ 1370 SMRRTEELIY 1380 LSQKIEFECK 1390 IFPLISQSRW 1400 LVKSGELTAL 1410 EFSASPGLRR 1420 KLNTRPVHLH 1430 LFNDCLLLSR 1440 PREGSRFLVF 1450 DHAPFSSIRG 1460 EKCEMKLHGP 1470 HKNLFRLFLR 1480 QNTQGAQAEF 1490 LFRTETQSEK 1500 LRWISALAMP 1510 REELDLLECY 1520 NSPQVQCLRA 1530 YKPRENDELA 1540 LEKADVVMVT 1550 QQSSDGWLEG 1560 VRLSDGERGW 1570 FPVQQVEFIS 1580 NPEVRAQNLK 1590 EAHRVKTAKL QLVEQQA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0071944	cell periphery
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0002102	podosome
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity
Molecular Function	GO:0008289	lipid binding
Biological Process	GO:0035556	intracellular signal transduction
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction
Biological Process	GO:0032956	regulation of actin cytoskeleton organization
Biological Process	GO:0051493	regulation of cytoskeleton organization
Biological Process	GO:0043087	regulation of GTPase activity
Biological Process	GO:0051056	regulation of small GTPase mediated signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.