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Overview

Uniprot IDQ12788
Protein NameTransducin beta-like protein 3
Gene NameTBL3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
458 LPKALLSKNTAPDNG

Function

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome

Protein Sequence

10 MAETAAGVGR 20 FKTNYAVERK 30 IEPFYKGGKA 40 QLDQTGQHLF 50 CVCGTRVNIL 60 EVASGAVLRS 70 LEQEDQEDIT 80 AFDLSPDNEV 90 LVTASRALLL 100 AQWAWQEGSV 110 TRLWKAIHTA 120 PVATMAFDPT 130 STLLATGGCD 140 GAVRVWDIVR 150 HYGTHHFRGS 160 PGVVHLVAFH 170 PDPTRLLLFS 180 SATDAAIRVW 190 SLQDRSCLAV 200 LTAHYSAVTS 210 LAFSADGHTM 220 LSSGRDKICI 230 IWDLQSCQAT 240 RTVPVFESVE 250 AAVLLPEEPV 260 SQLGVKSPGL 270 YFLTAGDQGT 280 LRVWEAASGQ 290 CVYTQAQPPG 300 PGQELTHCTL 310 AHTAGVVLTA 320 TADHNLLLYE 330 ARSLRLQKQF 340 AGYSEEVLDV 350 RFLGPEDSHV 360 VVASNSPCLK 370 VFELQTSACQ 380 ILHGHTDIVL 390 ALDVFRKGWL 400 FASCAKDQSV 410 RIWRMNKAGQ 420 VMCVAQGSGH 430 THSVGTVCCS 440 RLKESFLVTG 450 SQDCTVKLWP 460 LPKALLSKNT 470 APDNGPILLQ 480 AQTTQRCHDK 490 DINSVAIAPN 500 DKLLATGSQD 510 RTAKLWALPQ 520 CQLLGVFSGH 530 RRGLWCVQFS 540 PMDQVLATAS 550 ADGTIKLWAL 560 QDFSCLKTFE 570 GHDASVLKVA 580 FVSRGTQLLS 590 SGSDGLVKLW 600 TIKNNECVRT 610 LDAHEDKVWG 620 LHCSRLDDHA 630 LTGASDSRVI 640 LWKDVTEAEQ 650 AEEQARQEEQ 660 VVRQQELDNL 670 LHEKRYLRAL 680 GLAISLDRPH 690 TVLTVIQAIR 700 RDPEACEKLE 710 ATMLRLRRDQ 720 KEALLRFCVT 730 WNTNSRHCHE 740 AQAVLGVLLR 750 REAPEELLAY 760 EGVRAALEAL 770 LPYTERHFQR 780 LSRTLQAAAF 790 LDFLWHNMKL 800 PVPAAAPTPW ETHKGALP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030686 90S preribosome
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0032040 small-subunit processome
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0034511 U3 snoRNA binding
Biological Process GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process GO:0030490 maturation of SSU-rRNA
Biological Process GO:0042274 ribosomal small subunit biogenesis

Reference

PMID: N/A